文献类型：期刊文献

英文题名：The antidepressant-like effect of bacopaside I: Possible involvement of the oxidative stress system and the noradrenergic system

作者：Liu, Xiaojun[1];Liu, Fang[1];Yue, Rongcai[1];Li, Yuanyuan[1];Zhang, Jigang[1];Wang, Shuping[1];Zhang, Shoude[1];Wang, Rui[2,3];Shan, Lei[1];Zhang, Weidong[1,4]

机构：[1]Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China;[2]E China Univ Sci & Technol, Dept Pharmaceut Sci, Sch Pharm, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[4]Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200030, Peoples R China

年份：2013

卷号：110

起止页码：224

外文期刊名：PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000327112200029)】；

基金：The work was supported by program NCET Foundation, NSFC (30725045 and 81072627), partially supported by Global Research Network for Medicinal Plants (GRNMP) and King Saud University, Shanghai Leading Academic Discipline Project(B906), FP7-PEOPLE-IRSES-2008 (TCMCANCER Project 230232), Key laboratory of drug research for special environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (10DZ2251300) and the Scientific Foundation of Shanghai China (09DZ1975700, 09DZ1971500, 10DZ1971700), National Major Project of China (2011ZX09307-002-03), National Key Technology R&D Program of China (2012BAI29B06), Pujiang talent project of Shanghai (11PJ1402300) and the 111 Project (grant no. B07023), and Shanghai Key Laboratory of New Drug Design from Shanghai Science and Technology Committee [11DZ2260600].

语种：英文

外文关键词：Bacopaside I; Antidepressant-like effect; Antioxidant activation; Noradrenergic; Forced swim; Tail suspension

摘要：In the present study, the antidepressant-like effect of bacopaside I, a saponin compound present in the Bacopa monniera plant, was evaluated by behavioral and neurochemical methods. Bacopaside 1(50, 15 and 5 mg/kg) was given to mice via oral gavage for 7 successive days. The treatment significantly decreased the immobility time in mouse models of despair tests, but it did not influence locomotor activity. Neurochemical assays suggested that treatment by bacopaside 1(50, 15 and 5 mg/kg) improved brain antioxidant activity to varying degrees after the behavioral despair test. Bacopaside I (15 and 5 mg/kg) significantly reversed reserpine-induced depressive-like behaviors, including low temperature and ptosis. Conversely, bacopaside I did not affect either brain MAO-A or MAO-B activity after the behavioral despair test in mice. Additionally, 5-hydroxytryptophan (a precursor of 5-serotonin) was not involved in the antidepressant-like effect of bacopaside I. These findings indicated that the antidepressant-like effect of bacopaside I might be related to both antioxidant activation and noradrenergic activation, although the exact mechanism remains to be further elucidated. (C) 2013 Elsevier Inc. All rights reserved.