文献类型：期刊文献

英文题名：Tannic acid-loaded mesoporous silica for rapid hemostasis and antibacterial activity

作者：Wang, Chengwei[1,2,3];Zhou, Huayi[1,2];Niu, Haoyi[1,2];Ma, Xiaoyu[1,2];Yuan, Yuan[1,3];Hong, Hua[1,3];Liu, Changsheng[1,2]

机构：[1]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China;[3]Shanghai Wego Biol Technol Co Ltd, Shanghai 200237, Peoples R China

年份：2018

卷号：6

期号：12

起止页码：3318

外文期刊名：BIOMATERIALS SCIENCE

收录：;EI(收录号：20184806150111);WOS:【SCI-EXPANDED(收录号:WOS:000450897100015)】；

基金：The authors wish to express their gratitude to the financial supports from the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002), Science and Technology Commission Shanghai Municipality (16441902800), 111 Project (B14018), and the Fundamental Research Funds for the Central Universities (222201718002).

语种：英文

外文关键词：Flavonoids - Grafting (chemical) - Blood - Bacteria - Tannins

摘要：Massive blood loss and bacterial infection are major challenges for global public health. In this study, we developed tannic acid (TA)-loaded mesoporous silica (MS) nanoparticles for both hemorrhage control and effective antibacterium via covalent conjugation and electrostatic adsorption. The TA-absorbed MS could significantly relieve hemolysis and facilitate blood contact, therefore efficiently promoting protein adhesion and the contact activation pathway of the coagulation cascade with desirable hemostasis. Comparably, with increasing TAs absorption, the bleeding control and antibacterial performance were improved simultaneously, especially for 15TMS. Hemostasis tests demonstrated that the 15TMS could reduce the hemostatic time by 65% both in vitro and in vivo, with lower blood loss and could exhibit better antibacterial activities against Staphylococcus aureus and Staphylococcus epidermidis as well as promote wound healing. However, the TAs-loaded MS via chemical grafting (15T-g-MS) significantly reduced the surface area of MS, by replacing the Si-OH on the MS, and thus it exhibited worse bleeding control and antibacterial efficacy than 15TMS. Furthermore, all the samples exhibited excellent cell viability. Based on these results, it can be concluded that the 15TMS would be a promising material platform for designing hemostats in more extensive clinical application.