文献类型：期刊文献

英文题名：Microwave-Assisted Decarboxylative Three-Component Coupling of a 2-Oxoacetic Acid, an Amine, and an Alkyne

作者：Feng, Huangdi[1,2];Ermolat'ev, Denis S.[1];Song, Gonghua[2];Van der Eycken, Erik V.[1]

机构：[1]Katholieke Univ Leuven, Dept Chem, LOMAC, B-3001 Heverlee, Belgium;[2]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2011

卷号：76

期号：18

起止页码：7608

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20113814336299);WOS:【SCI-EXPANDED(收录号:WOS:000294702000040)，CCR-EXPANDED(收录号:WOS:000294702000040)】；

基金：The authors wish to thank the FWO (Fund for Scientific Research-Flanders (Belgium)) and the Research Fund of the University of Leuven for financial support to the laboratory. D.S. E. is grateful to the FWO for obtaining a postdoc fellowship. H.F. thanks the China Scholarship Council for financial support.

语种：英文

外文关键词：Hydrocarbons

摘要：A novel and efficient microwave-assisted decarboxylative three-component coupling of a 2-oxoacetic acid, an amine, and an alkyne (OA(2)-coulpling) has been developed. This new multicomponent coupling constitutes an efficient approach for the synthesis of polysubstituted propargylamines in the presence of a catalytic amount of copper(I) catalyst.