文献类型：期刊文献

中文题名：Chiral iminophosphorane catalyzed asymmetric Henry reaction of α,β-alkynyl ketoesters

作者：Yanxia Zhang[1,2];Xin-Yan Wu[1,2];Jianwei Han[1,2]

机构：[1]Key Laboratory for Advanced Materials,Institute of Fine Chemicals,School of Chemistry&Molecular Engineering,East China University of Science and Technology,Shanghai 200237,China;[2]Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis,Shanghai Institute of Organic Chemistry,The Chinese Academy of Sciences,Shanghai 200032,China

年份：2019

卷号：30

期号：8

起止页码：1519

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报(英文版)

收录：CSTPCD;;Scopus;CSCD:【CSCD2019_2020】；PubMed;

基金：supported by grants from National Key Program(No.2016YFA0200302,Study on application and preparation of aroma nanocomposites);National Natural Science Foundation of China(NSFC,No.21472213);Croucher Foundation(Hong Kong)in the form of a CAS-Croucher Foundation Joint Laboratory Grant

语种：英文

中文关键词：Organocatalysis;Iminophosphorane;Nitroaldol;Henry;reaction;Alkynyl;ketoesters

摘要：α,β-Alkynyl ketoesters were introduced to the enantioselective Henry reaction(nitroaldol condensation)with nitromethane catalyzed by tartaric acid derived chiral iminophosphoranes.As such,a variety of optically activeβ-nitro-substituted tertiary alcohols bearing alkyne moieties were obtained in good to excellent yields(42%–99%)and moderate to good level of enantiomeric excess(up to 87%ee).