文献类型：期刊文献

英文题名：Type I photosensitizer based on AIE chromophore tricyano-methylene-pyridine for photodynamic therapy

作者：Pan, Chao;Zhao, Weijun;Zhao, Xiaolei;Liu, Zhenxing;Li, Xiangyu;Lyu, Yanting;Wu, Xupeng;Zhu, Zhirong;Zhu, Wei-Hong;Wang, Qi[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Joint Int Res Lab Precis Chem & Mol Engn,Sch Chem, Shanghai 200237, Peoples R China

年份：2023

卷号：4

期号：3

起止页码：324

外文期刊名：GREEN CHEMICAL ENGINEERING

收录：EI(收录号：20224313013788);WOS:【ESCI(收录号:WOS:001072943700001)】；

基金：This work was supported by the NSFC Science Center Program (21788102) , NSFC/China (91959202, 21974047, and 21622602) , and Shanghai Municipal Science and Technology Major Project (2018SHZDZX03) .

语种：英文

外文关键词：Aggregation-induced emission; Near-infrared emission; Photodynamic therapy; Type I; ROS

摘要：Image guided photodynamic therapy (PDT) combines fluorescence tracing and phototherapy, which can achieve a more accurate and effective treatment effect. However, traditional photosensitizers are limited by the aggregation-caused fluorescence quenching (ACQ) effect and low reactive oxygen species (ROS) generation in a hypoxic environment, resulting in poor imaging and treatment effect. Herein, we report a tricyano-methylenepyridine (TCM)-based Type I aggregation-induced emission (AIE) photosensitizer (TCM-MBP), the strong electron acceptance (D-A) effect extends the wavelength to near-infrared (NIR) region to reduce the autofluorescence interference, and oxygen atoms provide lone pair electrons to enhance the inter system crossing (ISC) rate, thereby promoting the generation of more triplet states to produce ROS. The AIE photosensitizer TCM-MBP exhibited low oxygen dependence, NIR emission, and higher ROS production compared to commercially available Ce 6 and RB. After encapsulation with DSPE-PEG2000, TCM-MBP nanoparticles (TCM-MBP NPs) could penetrate to visualize cells and efficiently kill cancer cells upon light irradiation. This study provides an oxygenindependent AIE photosensitizer, which has great potential to replace the commercial ACQ photosensitizers.