文献类型：期刊文献

英文题名：Chiral Pyrrolidine Sulfonamide Catalyzed Enantioselective Michael Addition of Cyclohexanones to Maleimides

作者：Wang, Jian[2];Zhang, Man-Man[1];Zhang, Shieli[2];Xu, Zi-An[1];Li, Hao[3];Yu, Xin-Hong[1];Wang, Wei[1,2,3]

机构：[1]E China Univ Sci & Technol, Dept Med Chem, Sch Pharm, Shanghai 200237, Peoples R China;[2]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA;[3]Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Grad Sch, Shanghai 201203, Peoples R China

年份：2011

期号：4

起止页码：473

外文期刊名：SYNLETT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000287575400006)，CCR-EXPANDED(收录号:WOS:000287575400006)】；

基金：We are grateful for the National Science Foundation of China (20972051, X.-H.Y.), the Science and Technology Commission of Shanghai Municipality (08430703900 and 08431901800, X.-H.Y.), the Thousand Talents Program (W. W.), the China 111 Project (Grant No. B07023, W. W.), and the University of New Mexico RAC program (W. W.) for the support of this research. The Bruker X8 X-ray diffractometer was purchased via an NSF CRIF: MU award to the University of New Mexico, CHE-0443580. We also thank Dr. Eileen N. Duesler for her X-ray crystal structural analysis.

语种：英文

外文关键词：cyclic ketones; maleimides; Michael reaction; pyrrolidine sulfonamide

摘要：An organocatalytic enantioselective conjugate addition of cyclohexanones to maleimides has been developed. The process catalyzed by a (S)-pyrrolidine sulfonamide affords synthetically and medicinally useful chiral succinimides under mild reaction conditions.