文献类型：期刊文献

英文题名：A convenient one-pot synthesis of formamide derivatives using thiamine hydrochloride as a novel catalyst

作者：Lei, Min[1];Ma, Lei[1];Hu, Lihong[1,2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

年份：2010

卷号：51

期号：32

起止页码：4186

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000280345800007)，CCR-EXPANDED(收录号:WOS:000280345800007)】；

基金：This work was supported by the Chinese National Science and Technology Major Project 'Key New Drug Creation and Manufacturing Program' (Grants 2009ZX09301-001, 2009ZX09102), the Chinese National High-Tech R&D Program (Grants 2007AA 02Z147), the National Natural Science Foundation of China (Grants 90713046, 30772638, 30925040), and CAS Foundation (grant KSCX2-YW-R-179).

语种：英文

摘要：Formamide derivatives have been synthesized in excellent yields from amine and formic acid in the presence of a catalytic amount of thiamine hydrochloride (VB(1)) at 80 degrees C. The advantages of this method are the use of a cheap, stable, non-toxic, and readily available catalyst, easy work-up, improved yields, and solvent-free conditions. (C) 2010 Elsevier Ltd. All rights reserved.