文献类型：期刊文献

英文题名：An exo- and enantioselective 1,3-dipolar cycloaddition of azomethine ylides with alkylidene malonates catalyzed by a N,O-ligand/Cu(OAc)2-derived chiral complex

作者：Wang, Ming[1]; Wang, Zheng[1]; Shi, Yu-Hua[1]; Shi, Xiao-Xin[1]; Fossey, John S.[2]; Deng, Wei-Ping[1]

机构：[1] School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China; [2] School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom

年份：2011

卷号：50

期号：21

起止页码：4897

外文期刊名：Angewandte Chemie - International Edition

收录：EI(收录号：20111913976194)

语种：英文

外文关键词：Copper - Ligands - Nitrogen - Molecular sieves - Cycloaddition - Enantioselectivity

摘要：An exo-lent catalyst: An N,O-ligand/Cu(OAc)2 derived chiral complex is an excellent catalyst for inducing asymmetry in the catalytic enantioselective 1,3-dipolar cycloadditions of azomethine ylides with various alkylidene malonates. A series of highly functionalized exo-pyrrolidines were obtained in excellent yields (80-99 %) and enantioselectivities (91-99 %ee; see scheme; M.S.: molecular sieve). Copyright ? 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.