文献类型：期刊文献

中文题名：Molecularly near-infrared fluorescent theranostics for in vivo tracking tumor-specific chemotherapy

英文题名：Molecularly near-infrared fluorescent theranostics for in vivo tracking tumor-specific chemotherapy

作者：Chenxu Yan[1];Limin Shi[1];Zhiqian Guo[1];Weihong Zhu[1]

机构：[1]Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering,Feringa Nobel Prize Scientist Joint Research Center,Shanghai Key Laboratory of Functional Materials Chemistry,Institute of Fine Chemicals,School of Chemistry and Molecular Engineering,East China University of Science and Technology

年份：2019

卷号：30

期号：10

起止页码：1849

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2019_2020】；PubMed;

基金：supported by the National Natural Science Foundation of China (Nos.2 788102, 21421004, 21636002, 21622602 and 21908060);National Key Research and Development Program (No. 2017YFC0906902);Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03);the Innovation Program of Shanghai Municipal Education Commission, Scientific Committee of Shanghai (No. 15XD1501400);China Postdoctoral Science Foundation (No. 2019M651417)

语种：英文

中文关键词：Near-infrared;fluorescence;Fluorescent;probe;Theranostic;Prodrug;Chemotherapy

外文关键词：Near-infrared fluorescence;Fluorescent probe;Theranostic;Prodrug;Chemotherapy

摘要：Molecularly near-infrared(NIR) theranostics, combining in vivo sensing and tumor-specific therapeutic capability within one molecular system, have received considerable attention in recent years. Compared with the visible fluorescence imaging, NIR imaging(emission wavelength at 650–900 nm) possesses unique advantages including the minimum photodamage to biological samples, deep penetration, and low interference from auto-fluorescence. In over past decades, there has been an explosive development in the design of molecular imaging contrasts and imaging-guided therapeutics. In this review, we have sumarried the strategies of the NIR theranostics for imaging and tumor-specific chemotherapy applications in living systems. It is noted that the molecularly NIR theranostic design strategy could address current challenges of real-time in vivo sense-and-release for the intelligent biosensing and personalized treatment.
Molecularly near-infrared(NIR) theranostics, combining in vivo sensing and tumor-specific therapeutic capability within one molecular system, have received considerable attention in recent years. Compared with the visible fluorescence imaging, NIR imaging(emission wavelength at 650–900 nm) possesses unique advantages including the minimum photodamage to biological samples, deep penetration, and low interference from auto-fluorescence. In over past decades, there has been an explosive development in the design of molecular imaging contrasts and imaging-guided therapeutics. In this review, we have sumarried the strategies of the NIR theranostics for imaging and tumor-specific chemotherapy applications in living systems. It is noted that the molecularly NIR theranostic design strategy could address current challenges of real-time in vivo sense-and-release for the intelligent biosensing and personalized treatment.