文献类型：期刊文献

英文题名：Graphene quantum dots in photodynamic therapy

作者：Chen, Jiayi[1];Wu, Wentian[2];Zhang, Fangwei[2];Zhang, Jiali[2];Liu, Hui[1];Zheng, Jing[1];Guo, Shouwu[2];Zhang, Jingyan[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Dept Elect Engn, Sch Elect Informat & Elect Engn, Shanghai 200240, Peoples R China

年份：2020

卷号：2

期号：10

起止页码：4961

外文期刊名：NANOSCALE ADVANCES

收录：;EI(收录号：20204509447749);WOS:【SCI-EXPANDED(收录号:WOS:000586010700061)】；

基金：This research was carried out with financial support from National Science Foundation of China (No. 21671065), the State Key Laboratory of Bioreactor Engineering (No. 2060204), the Shanghai Committee of Science and Technology (No. 11DZ2260600).

语种：英文

外文关键词：Medical applications - Graphene - Irradiation - Photosensitizers - Nanocrystals - Semiconductor quantum dots - Aromatic compounds

摘要：Graphene quantum dots (GQDs) have shown great promise in a variety of medical applications. Recently, it has been found that GQDs are also beneficial for photodynamic therapy (PDT). However, the findings of GQDs as PDT agents have been controversial in the literature. Herein, we investigate the photoactivity of single-atomic-layered GQDs by examining their ability to generate singlet oxygen (O-1(2)) under irradiation and their effects on the photoactivity of photosensitizers. We demonstrate that the GQDs with lateral sizes of similar to 5 or 20 nm are photo-inactive for they cannot generate O-1(2) under irradiation of either a 660 nm laser (105 mW cm(-2)) or a halogen light. Moreover, the GQDs inhibit the photoactivity of two classical photosensitizers, namely, methylene blue and methylene violet. The stronger interaction between the GQDs and the photosensitizer results in greater inhibition of GQDs. Besides, the large-sized GQDs exhibit stronger inhibition than the small-sized GQDs. The inhibitory effect of the GQDs on the photoactivity of photosensitizers is consistent with their photo-cytotoxicity. These results indicate that the single-atomic-layered GQDs are not potential PDT agents, but they may be helpful for photosensitizers by delivering them into the cells. The discrepancy between the current work and the literature is probably associated with the GQDs used.