文献类型：期刊文献

英文题名：Highly enantioselective Michael addition of α,α-disubstituted aldehydes to nitroolefins

作者：Guo, Xing-Tao[1,2];Sha, Feng[1,2];Wu, Xin-Yan[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2016

卷号：42

期号：7

起止页码：6373

外文期刊名：RESEARCH ON CHEMICAL INTERMEDIATES

收录：;EI(收录号：20160801996192);WOS:【SCI-EXPANDED(收录号:WOS:000385201000014)，CCR-EXPANDED(收录号:WOS:000385201000014)】；

基金：We are grateful for the financial support from National Natural Science Foundation of China (21242007, 21102043), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Chiral primary amine-thiourea; alpha,alpha-Disubstituted aldehydes; Enantioselective organocatalysis; Michael addition; Nitroolefins

摘要：A highly enantioselective Michael addition reaction of alpha,alpha-disubstituted aldehydes to beta-nitrostyrenes has been developed. In the presence of rosin-based chiral primary amine-thiourea, gamma-nitroaldehydes were afforded in excellent enantioselectivities (up to 99 % ee) with up to 99 % yield.