文献类型：期刊文献

英文题名：Extracts from Chinese herbs with anti-amyloid and neuroprotective activities

作者：Bednarikova, Zuzana[1];Gancar, Miroslav[1];Wang, Rui[2];Zheng, Lulu[2];Tang, Yun[2];Luo, Yating[2];Huang, Yan[2];Spodniakova, Barbora[1];Ma, Lei[2];Gazova, Zuzana[1]

机构：[1]Slovak Acad Sci, Inst Expt Phys, Dept Biophys, Watsonova 47, Kosice 04001, Slovakia;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2021

卷号：179

起止页码：475

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：;EI(收录号：20241015685319);WOS:【SCI-EXPANDED(收录号:WOS:000645618600011)】；

基金：This work was supported by the Slovak Research and Development Agency [APVV-18-0284; APVV SK-CN-2017-0033]; Slovak Grant Agency VEGA [02/0145/17, 02/0176/21 and 02/0030/18]; the Operational Programme Integrated Infrastructure (OPII) funded by the ERDF [ITMS2014+ 313011T553 DIAGNAD]; the China 111 Project (Grant BP0719034) and Exchange project of the 8th regular meeting of China Slovak intergovernmental cooperation, Chinese Ministry of Science and Technology ([2017] NO.21).

语种：英文

外文关键词：Amyloid beta(42) peptide; Fibrils destruction; Chinese herbs; Neuroprotection

摘要：Many Chinese herbs are well known for their neuroprotective and anti-oxidant properties. Extracts of Salvia miltiorrhiza and Anemarrhenae asphodeloides, tanshinone IIA (tanIIA), salvianolic acid B (Sal B) and sarsasapogenin (ML-1), were selected to study their dissociation potential towards A beta(42) peptide fibrils and neuroprotective effect on cells. Moreover, derivatives of sarsasapogenin (ML-2, ML-3 and ML-4) have been prepared by the addition of modified carbamate moiety. TanIIA and Sal B have shown to possess a strong ability to dissociate A beta(42) fibrils. The dissociation potential of ML-1 increased upon the introduction of carbamate moiety with N-heterocycles. In silico data revealed that derivatives ML-4 and Sal B interact with A beta(42) regions responsible for fibril stabilization through hydrogen bonds. Contrary, tanIIA binds close to a central hydrophobic region, which may lead to destabilization of fibrils. Sarsasapogenin derivative ML-2 decreased nitride oxide production, and derivative ML-4 enhanced the growth of neurites. The reported data highlight the possibility of using active compounds to design novel treatment agents for Alzheimer's disease. (C) 2021 Elsevier B.V. All rights reserved.