文献类型：期刊文献

英文题名：Incorporating redox-sensitive nanogels into bioabsorbable nanofibrous membrane to acquire ROS-balance capacity for skin regeneration

作者：Zhang, Shihao[1];Li, Yamin[4];Qiu, Xiaofeng[1];Jiao, Anqi[1];Luo, Wei[1];Lin, Xiajie[1];Zhang, Xiaohui[1];Zhang, Zeren[1];Hong, Jiachan[1];Cai, Peihao[1];Zhang, Yuhong[5];Wu, Yan[3];Gao, Jie[2];Liu, Changsheng[1];Li, Yulin[1,5]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Sch Mat Sci & Engn, Key Lab Ultrafine Mat,Minist Educ,State Key Lab B, Shanghai 200237, Peoples R China;[2]Shanghai Univ, Inst Translat Med, Shanghai 200444, Peoples R China;[3]Mudanjiang Med Univ, Heilongjiang Key Lab Antifibrosis Biotherapy, Mudanjiang 157011, Peoples R China;[4]Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai 200233, Peoples R China;[5]Hubei Univ, Hubei Collaborat Innovat Ctr Adv Organ Chem Mat, Minist Educ, Key Lab Synth & Applicat Organ Funct Mol,Coll Che, Wuhan 430062, Peoples R China

年份：2021

卷号：6

期号：10

起止页码：3461

外文期刊名：BIOACTIVE MATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000672673500034)】；

基金：The research was supported by National Key R&D Program of China (2018YFE0201500, 2017YFB0309300), National Natural Science Foundation of China (81772317, 51973060, 82072051, 81771964), National Natural Science Foundation of China for Innovative Research Groups (51621002), and Natural Science Foundation of Heilongjiang Province (LH2020H076), Shanghai International Cooperation Program (15520721200), and Central Universities (WD1714002). The funding grants from Joint research project of important diseases in Xuhui District (XHLHGG201802), and Fundamental Research Funds for the Shanghai Municipal Commission of Health and Family Planning (201740034) were also acknowledged.

语种：英文

外文关键词：Polylactide; Nanofibrous membrane; Redox sensitivity; ROS-Balance capacity; Skin regeneration

摘要：Facing the high incidence of skin diseases, it is urgent to develop functional materials with high bioactivity for wound healing, where reactive oxygen species (ROS) play an important role in the wound healing process mainly via adjustment of immune response and neovasculation. In this study, we developed a kind of bioabsorbable materials with ROS-mediation capacity for skin disease therapy. Firstly, redox-sensitive poly(N-isopropylacrylamide-acrylic acid) (PNA) nanogels were synthesized by radical emulsion polymerization method using a disulfide molecule as crosslinker. The resulting nanogels were then incorporated into the nanofibrous membrane of poly(L-lactic acid) (PLLA) via airbrushing approach to offer bioabsorbable membrane with redox-sensitive ROS-balance capacity. In vitro biological evaluation indicated that the PNA-contained bioabsorbable membrane improved cell adhesion and proliferation compared to the native PLLA membrane. In vivo study using mouse wound skin model demonstrated that PNA-doped nanofibrous membranes could promote the wound healing process, where the disulfide bonds in them were able to adjust the ROS level in the wound skin for mediation of redox potential to achieve higher wound healing efficacy.