文献类型：期刊文献

英文题名：Reverse milling-sputtering technology to develop scalable microneedle patches for analgesia

作者：Jin, Lili[1,2,3];He, Miao[2,3];Chen, Ying[2,3];Liu, Changsheng[1,4];He, Hongyan[1,2,3,4]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat Minist Educ, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Key Lab Ultrafine Mat Minist Educ, Shanghai 200237, Peoples R China

年份：2023

卷号：36

外文期刊名：MATERIALS TODAY COMMUNICATIONS

收录：;EI(收录号：20233014441883);WOS:【SCI-EXPANDED(收录号:WOS:001047819600001)】；

基金：This work was supported by National Key Research and Development Plan Strategic International Science and Technology Innovation Cooperation Key Projects (Grant No. SQ2018YF020328) , National Natural Science Foundation of China for Innovative Research Groups (Grant No. 51621002) and Fundamental Research Funds for the Central Universities, State Administration of Foreign Experts Affairs P.R. China (Grant No. B14018) .

语种：英文

外文关键词：Microneedle patches; Reverse milling -sputtering; Analgesia

摘要：With the burst of pandemic disease in recent years, the demand of microneedle patches (MNPs) has increased rapidly for patient-friendly therapeutic treatment to alleviate the patient suffering. Traditional fabrication processes are complicated and time-consuming, greatly limiting their biomedical applications. To obtain MNPs with designable types for clinic needs, a reverse milling-sputtering technology (RMST) was developed in this work to fabricate scalable masters with gold sputtering for better demoldability. The RMST simplicity allowed for the encapsulation of the clinical analgesic lidocaine into the cryo-MNP (C-MNP), which delivered the drug through the skin to achieve the analgesic efficiency of 96.3%, implying the great potential for clinic analgesia. In addition, RMST also enables the fabrication of MNPs with well-defined shape (50-& mu;m tip diameter), a large area of 35 x 35 mm2 and various polymer materials. RMST can be a scalable and cost-effective strategy to develop MNPs with individual design, holding great potential for transdermal therapy.