文献类型：期刊文献

英文题名：Solubility correlation and thermodynamic analysis of two forms of Metaxalone in different pure solvents

作者：Hong, Minghuang[1];Wu, Shiwang[1];Qi, Minghui[1];Ren, Guobin[1]

机构：[1]E China Univ Sci & Technol, Lab Pharmaceut Crystal Engn & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2016

卷号：409

起止页码：1

外文期刊名：FLUID PHASE EQUILIBRIA

收录：;EI(收录号：20153901301929);WOS:【SCI-EXPANDED(收录号:WOS:000367860400001)】；

基金：This work was supported by National Natural Science Foundation of China (No. 81102391) and the Shanghai Committee of Science and Technology (Grant 12DZ1930702).

语种：英文

外文关键词：Solubility; Thermodynamic models; Endothermic; Entropy driven; Nonspontaneous

摘要：The solubility data of two forms of MTX in ethanol, isopropanol, ethyl acetate and toluene was measured over the temperature range from 283.15 K to 323.15 K using shake flask method under atmospheric pressure. The experimental results indicated that the solubility of both forms of MTX increased as the temperature increased. And it was clear that the solubility of form B was lower than the solubility of form A at the same state. The experimental data was correlated by the modified Apelblat equation, the polynomial equation and the Buchowski-Ksiazczak lambda equation. All these thermodynamic models gave satisfactory correlation results, with the polynomial equation showing better fitting degree than the other two equations. The results of thermodynamic parameters (triangle H-d > 0, triangle S-d > 0, triangle G(d) > 0) indicated an endothermic, entropy driven and nonspontaneous dissolution process of MTX in selected pure solvents. (c) 2015 Elsevier B.V. All rights reserved.