文献类型：期刊文献

英文题名：Specific Synergist for Neonicotinoid Insecticides: IPPA08, a cis-Neonicotinoid Compound with a Unique Oxabridged Substructure

作者：Bao, Haibo[1];Shao, Xusheng[2];Zhang, Yixi[1];Deng, Yayun[2];Xu, Xiaoyong[2];Liu, Zewen[1];Li, Zhong[2]

机构：[1]Nanjing Agr Univ, Coll Plant Protect, Key Lab Integrated Management Crop Dis & Pests, Minist Educ, Weigang 1, Nanjing 210095, Jiangsu, Peoples R China;[2]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Meilong Rd 130, Shanghai 200237, Peoples R China

年份：2016

卷号：64

期号：25

起止页码：5148

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20162702568990);WOS:【SCI-EXPANDED(收录号:WOS:000378984500002)】；

基金：This work was supported by the National Natural Science Foundation of China (31322045 and 31130045) and the Jiangsu Science Fund for Distinguished Young Scholars (BK20130028).

语种：英文

外文关键词：neonicotinoid; insecticide synergist; detoxification enzyme; nicotinic acetylcholine receptors

摘要：Insecticide synergists are key components to increase the control efficacy and reduce active ingredient use. Here, we describe a novel insecticide synergist with activity specific for insecticidal neonicotinoids. The synergist IPPA08, a cis configuration neonicotinoid compound with a unique oxabridged substructure, could increase the toxicity of most neonicotinoid insecticides belonging to the Insecticide Resistance Action Committee (IRAC) 4A subgroup against a range of insect species, although IPPA08 itself was almost inactive to insects at synergistic concentrations. Unfortunately, similar effects were observed on the honey bee (Apis mellifera) and the brown planthopper (Nilaparvata lugens), resistant to imidacloprid. IPPA08 did not show any effects on toxicity of insecticides with different targets, which made us define it as a neonicotinoid-specific synergist. Unlike most insecticide synergists, by inhibition of activities of detoxification enzymes, IPPA08 showed no effects on enzyme activities. The results revealed that IPPA08 worked as a synergist through a distinct way. Although the modulating insect nicotinic acetylcholine receptors (nAChRs, targets of neonicotinoid insecticides) were supposed as a possible mode of action for IPPA08 as a neonicotinoid-specific synergist, direct evidence is needed in further studies. In insect pest control, IPPA08 acts as a target synergist to increase neonicotinoid toxicity and reduce the amount of neonicotinoid used. Combinations of IPPA08 and insecticidal neonicotinoids may be developed into new insecticide formulations. In summary, combining an active ingredient with a "custom" synergist appears to be a very promising approach for the development of effective new insecticide products.