文献类型：期刊文献

英文题名：Structural diversity of surfactin lipopeptides and their molecular behaviors in solutions and at interfaces

作者：Qin, Wan-Qi[1];Liu, Yi-Fan[1,2,3];Gang, Hong-Ze[1,2,3];Liu, Jin-Feng[4];Zhou, Lei[1,2,3];Yang, Shi-Zhong[1,2,3];Mu, Bo-Zhong[1,2,3]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Shanghai Collaborat Innovat Ctr Biomfg Technol, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, MOE Engn Res Ctr Microbial Enhanced Oil Recovery, Shanghai 200237, Peoples R China;[4]Daqing Huali Biotechnol Co Ltd, Daqing 163511, Heilongjiang, Peoples R China

年份：2025

卷号：343

外文期刊名：ADVANCES IN COLLOID AND INTERFACE SCIENCE

收录：;EI(收录号：20252618663459);WOS:【SCI-EXPANDED(收录号:WOS:001522234800001)】；

基金：This work was supported by the National Key Research and Devel-opment Program of China (No. 2022YFC2105200) , the Fundamental Research Funds for the Central Universities of China (JKJ01231714) and the Research Program of State Key Laboratory of Bioreactor Engineering.

语种：英文

外文关键词：surfactin; lipopeptide biosurfactant; microorganism; structural diversity; molecular behavior

摘要：Surfactin, a representative cyclic lipopeptide biosurfactant produced by diverse microorganisms, is widely recognized as one of the most effective biosurfactants to date. Due to its remarkable surface and interfacial activities alongside significant biological properties, surfactin presents a sustainable complement to conventional surfactants and antibiotics. This review provides a comprehensive overview of recent advancements in the biosynthesis, structural characterization, molecular behaviors, and potential applications of surfactin. We first explore its microbial origins and biosynthetic pathways, followed by an in-depth discussion of laboratory-scale production process, encompassing microbial screening, fermentation process, purification, and structural identification using various characterization techniques. The structural diversity of surfactin, which varies in the length (C11-C18) and configuration of hydrophobic chain and the amino acid composition and methylation of heptapeptide, is systematically summarized. Furthermore, we highlight the colloidal and interfacial properties of surfactin, emphasizing the interplay between molecular structures, micelle formation, self-assembly behaviors, adsorption dynamics, and environmental factors. These exceptional properties position surfactin as an ideal candidate for exploitation in a wide range of applications, including enhanced oil recovery, environmental bioremediation, and innovations in the daily chemical and pharmaceutical fields.