文献类型：期刊文献

英文题名：Rational Design of Near-Infrared Aggregation-Induced-Emission Active Probes: In Situ Mapping of Annyloid-β Plaques with Ultrasensitivity and High-Fidelity

作者：Fu, Wei[1,2];Yan, Chenxu[1,2];Guo, Zhiqian[1,2];Zhang, Jingjing[3];Zhang, Haiyan[3];Tian, He[1,2];Zhu, Wei-Hong[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Sch Chem & Mol Engn,Shanghai Key Lab Funct Mat Ch, Feringa Nobel Prize Scientist Joint Res Ctr,Inst, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China

年份：2019

卷号：141

期号：7

起止页码：3171

外文期刊名：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000459642000051)】；

基金：This work was supported by NSFC/China (21788102, 21421004, 21636002, 21622602 and 81522045), National Key Research and Development Program (2017YFC0906902 and 2016YFA0200300), Shanghai Municipal Science and Technology Major Project (Grant 2018SHZDZX03), the Innovation Program of Shanghai Municipal Education Commission, Scientific Committee of Shanghai (15XD1501400), and Programme of Introducing Talents of Discipline to Universities (B16017).

语种：英文

摘要：High-fidelity mapping of amyloid-beta (A beta) plaques is critical for the early detection of Alzheimer's disease. However, in vivo probing of A beta plaques by commercially available thioflavin derivatives (ThT or ThS) has proven to be extremely limited, as evident by the restriction of enrichment quenching effect, low signal-to-noise (S/N) ratio, and poor blood-brain barrier (BBB) penetrability. Herein, we demonstrate a rational design strategy of near-infrared (NIR) aggregation-induced emission (AIE)-active probes for A beta plaques, through introducing a lipophilic pi-conjugated thiophene-bridge for extension to NIR wavelength range with enhancement of BBB penetrability, and tuning the substituted position of the sulfonate group for guaranteeing specific hydrophilicity to maintain the fluorescence-off state before binding to A beta deposition. Probe QM-FN-SO3 has settled well the AIE dilemma between the lipophilic requirement for longer emission and aggregation behavior from water to protein fibrillogenesis, thus making a breakthrough in high-fidelity feedback on in vivo detection of A beta plaques with remarkable binding affinity, and serving as an efficient alternative to the commercial probe ThT or ThS.