文献类型：期刊文献

英文题名：Nanomaterial-based bone regeneration

作者：Li, Yulin[1];Liu, Changsheng[1]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China

年份：2017

卷号：9

期号：15

起止页码：4862

外文期刊名：NANOSCALE

收录：;EI(收录号：20171603582671);WOS:【SCI-EXPANDED(收录号:WOS:000399429800002)】；

基金：We are grateful for the financial support from the Key Program of the National Natural Science Foundation of China (31330028), the Shanghai Municipal Natural Science Foundation (15ZR1408500), and the Shanghai International Cooperation Program (15520711100). The 111 Project (B14018) is also acknowledged for their financial support.

语种：英文

外文关键词：Biomimetics - Bone - Nanocrystals

摘要：Bone diseases/injuries have been driving an urgent quest for bone substitutes for bone regeneration. Nanoscaled materials with bone-mimicking characteristics may create suitable microenvironments to guide effective bone regeneration. In this review, the natural hierarchical architecture of bone and its regeneration mechanisms are elucidated. Recent progress in the development of nanomaterials which can promote bone regeneration through bone-healing mimicry (e.g., compositional, nanocrystal formation, structural, and growth factor-related mimicking) is summarized. The nanoeffects of nanomaterials on the regulation of bone-related biological functions are highlighted. How to prepare nanomaterials with combinative bone-biomimicry features according to the bone healing process is prospected in order to achieve rapid bone regeneration in situ.