文献类型：期刊文献

英文题名：Facile Construction of Antimicrobial Surface via One-Step Co-Deposition of Peptide Polymer and Dopamine

作者：Wu, Yueming[1];She, Yunrui[2];Yan, Zi[2];Chen, Sheng[2];Wang, Jiangzhou[2];Dong, Alideertu[3];Wang, Jing[2];Liu, Runhui[1,2,4]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Res Ctr Biomed Mat, Shanghai Frontier Sci Res Base Optogenet Techn Cel, Shanghai 200237, Peoples R China;[3]Inner Mongolia Univ, Engn Res Ctr Dairy Qual & Safety Control Technol, Minist Educ, Hohhot 010021, Peoples R China;[4]East China Univ Sci & Technol, Shenzhen Res Inst, Shenzhen 518063, Peoples R China

年份：2024

卷号：24

期号：2

外文期刊名：MACROMOLECULAR BIOSCIENCE

收录：;EI(收录号：20233914799838);WOS:【SCI-EXPANDED(收录号:WOS:001070102900001)】；

基金：This research was supported by the National Natural Science Foundation of China (no. 52203162, 22075078), Program of Shanghai Academic/Technology Research Leader (20XD1421400), China National Postdoctoral Program for Innovative Talents (BX20220108), the China Postdoctoral Science Foundation (2021M701198), Free exploring basic research project at Shenzhen Research Institute of ECUST (2021Szvup042), Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry (Changchun Institute of Applied Chemistry, Chinese Academy of Sciences), the Open Project of Engineering Research Center of Dairy Quality and Safety Control Technology (Ministry of Education, R202201), and Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission). Authors thank for the support of the Analysis and Testing Center of School of Chemical Engineering, East China University of Science and Technology. The authors also thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization in this manuscript.

语种：英文

外文关键词：antimicrobial surface; drug-resistant bacteria; host defense peptide; one-step co-deposition; peptide polymer

摘要：The infections associated with implantable medical devices can greatly affect the therapeutic effect and impose a heavy financial burden. Therefore, it is of great significance to develop antimicrobial biomaterials for the prevention and mitigation of healthcare-associated infections. Here, a facile construction of antimicrobial surface via one-step co-deposition of peptide polymer and dopamine is reported. The co-deposition of antimicrobial peptide polymer DLL60BLG40 with dopamine (DA) on the surface of thermoplastic polyurethane (TPU) provides peptide polymer-modified TPU surface (TPU-DLL60BLG40). The antimicrobial test shows that the TPU-DLL60BLG40 surfaces of the sheet and the catheter both exhibit potent killing of 99.9% of methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli). In addition, the TPU-DLL60BLG40 surface also exhibits excellent biocompatibility. This one-step antimicrobial modification method is fast and efficient, implies promising application in surface antimicrobial modification of implantable biomaterials and medical devices. This study reports a facile construction of antimicrobial surface via one-step co-deposition of host defense peptide-mimicking peptide polymer and dopamine, with the killing efficacy of 99.9% against both Gram-positive bacteria and Gram-negative bacteria and excellent biocompatibility. The method is fast and effective and is a promising method for antimicrobial surface modification of implantable biomaterials and medical devices.image