文献类型：期刊文献

中文题名：载药明胶纳米粒子的制备及体外释药特性研究

英文题名：Preparation of Drug-Loaded Gelatin Nanoparticles and Released Drug Characterization in Vitro

作者：蔡梦军[1];朱以华[2];杨晓玲[2]

机构：[1]华东理工大学国家超细粉末工程研究中心,上海200237;[2]华东理工大学超细材料制备与应用教育部重点实验室

年份：2005

卷号：31

期号：5

起止页码：612

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;EI(收录号：2005479497646);Scopus;北大核心:【北大核心2004】；CSCD:【CSCD2011_2012】；

基金：国家自然科学基金(20276019);国家863计划(2002AA302208);上海市纳米专项(0243nm069)资助项目

语种：中文

中文关键词：纳米粒子;体外释药;特性研究;明胶;制备;激光粒度分析仪;药物载体;载药;高分子蛋白质

外文关键词：drug-loaded; gelatin nanoparticles; doxorubicin; sustained release in vitro

摘要：以生物可降解天然高分子蛋白质明胶为载体材料,阿霉素为药物材料,异丙醇为凝聚剂,采用单凝聚成球法,制备得到了阿霉素明胶纳米粒子。并对阿霉素明胶纳米粒子的粒径分布、载药量以及药物的体外释药等特性进行了考察。激光粒度分析仪测试结果表明阿霉素明胶粒子的粒径约为100 nm,粒径分布均匀,平均载药量为2.5μg/m g,而且阿霉素明胶粒子在体外的药物缓释效果显著,因此作为药物载体明胶纳米粒子具有广泛的应用前景。
Doxorubicin-gelatin nanoparticles were prepared by the coacervation method,using natural bidegrabable macromolecular protein-gelatin as the core material, doxorubicin as the entrapped pharmaceuticals,and isopropanol as the coacervation reagent.Particle size, drug loading capacity and drug release in vitro of the doxorubicin-gelatin nanoparticles were characterized.Using a laser scattering particle size analyzer, the mean particle size was found to be about 100 nm and uniformly distributed.The average loading capacity was about 2.5μg/mg.The sustained drug release effect of doxorubicin-gelatin nanoparticles was notable in vitro; therefore, the gelatin nanoparticles have potential applications as a drug-loading carrier.