文献类型：期刊文献

英文题名：Fluorescent probes for the detection of disease-associated biomarkers

作者：Dou, Wei-Tao[1,8];Han, Hai-Hao[1,8];Sedgwick, Adam C.[6];Zhu, Guo-Biao[1,8];Zang, Yi[2];Yang, Xin-Rong[3];Yoon, Juyoung[5];James, Tony D.[4,7];Li, Jia[2];He, Xiao-Peng[1,8]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai 201203, Peoples R China;[3]Fudan Univ, Zhongshan Hosp, Liver Canc Inst, Dept Liver Surg & Transplantat,Key Lab Carcinogene, Shanghai 200032, Peoples R China;[4]Univ Bath, Dept Chem, Bath BA2 7AY, England;[5]Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea;[6]Univ Texas Austin, Dept Chem, Austin, TX 78712 USA;[7]Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China;[8]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Joint Int Res Lab Precis Chem, Shanghai 200237, Peoples R China

年份：2022

卷号：67

期号：8

起止页码：853

外文期刊名：SCIENCE BULLETIN

收录：;EI(收录号：20220911707035);WOS:【SCI-EXPANDED(收录号:WOS:000804192500013)】；

基金：Xiao-Peng He thanks the National Natural Science Foundation of China (21788102, 91853201) , the Shanghai Municipal Science and Technology Major Project (2018SHZDZX03) , the International Cooperation Program of Shanghai Science and Technology Committee (17520750100) , the Projects from the Shanghai Science and Techonology Commission (19441905000) , the Fundamental Research Funds for the Central Universities (222201717003) , and the Programme of Introducing Talents of Discipline to Universities (B16017) for financial support. Wei-Tao Dou would like to thank the National Natural Science Foundation of China (22107028) , National Postdoctoral Program for Innovative Talents (BX20190115) , Shanghai Post-doctoral Excellence Program (2019044) , and China Postdoctoral Science Foundation (2020M681206) for financial support. Hai-Hao Han would like to thank the Project funded by China Postdoctoral Science Foundation (2020M681196) . Tony D. James wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01) .

语种：英文

外文关键词：Fluorescent probes; Fluorescence imaging; Biomarker detection; Chemical biology

摘要：Fluorescent probes have emerged as indispensable chemical tools to the field of chemical biology and medicine. The ability to detect intracellular species and monitor physiological processes has not only advanced our knowledge in biology but has provided new approaches towards disease diagnosis. In this review, we detail the design criteria and strategies for some recently reported fluorescent probes that can detect a wide range of biologically important species in cells and in vivo. In doing so, we highlight the importance of each biological species and their role in biological systems and for disease progression. We then discuss the current problems and challenges of existing technologies and provide our perspec-tive on the future directions of the research area. Overall, we hope this review will provide inspiration for researchers and prove as useful guide for the development of the next generation of fluorescent probes.CO 2022 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved.