文献类型：期刊文献

英文题名：Total Synthesis of Polyene Natural Product Dihydroxerulin by Mild Organocatalyzed Dehydrogenation of Alcohols

作者：Xie, Hexin[1];Zhang, Shilei[1];Li, Hao[2];Zhang, Xinshuai[1];Zhao, Sihan[1];Xu, Zian[2];Song, Xixi[1];Yu, Xinhong[2];Wang, Wei[1,2]

机构：[1]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA;[2]E Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2012

卷号：18

期号：8

起止页码：2230

外文期刊名：CHEMISTRY-A EUROPEAN JOURNAL

收录：;EI(收录号：20120814785824);WOS:【SCI-EXPANDED(收录号:WOS:000300500200009)，CCR-EXPANDED(收录号:WOS:000300500200009)】；

基金：Financial support of this research by the National Science Foundation (CHE-1057569, W.W.), the China 111 Project (Grant B07023, W.W.), East China University of Science & Technology (W.W.), the National Science Foundation of China (20972051, X.-H.Y.), the Shanghai Pujiang Program (11PJ1411900, H.L.), and the Science and Technology Commission of Shanghai Municipality (08430703900 and 08431901800, X.-H.Y.) is gratefully acknowledged.

语种：英文

外文关键词：dehydrogenation; dihydroxerulin; enals; organocatalysis; oxidative enamine catalysis; polyenes

摘要：Polyene synthesis: An efficient approach to the total synthesis of polyene natural product dihydroxrulin (1) is described. A novel, mild, direct organocatalytic IBX-mediated dehydrogenation process of simple alcohols to enals has been developed, which serves as a key step in the synthesis (see scheme). Copyright ? 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.