文献类型：期刊文献

英文题名：Amphoteric calix[8]arene-based complex for pH-triggered drug delivery

作者：Xue, Yan[1,2];Guan, Yong[2];Zheng, Anna[2];Xiao, Huining[1]

机构：[1]Univ New Brunswick, Dept Chem Engn, Fredericton, NB E3B 5A3, Canada;[2]E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai Key Lab Adv Polymer Mat,Sch Mat Sci & En, Shanghai 200237, Peoples R China

年份：2013

卷号：101

起止页码：55

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20124815730580);WOS:【SCI-EXPANDED(收录号:WOS:000313405300009)】；

基金：We thank NSERC Sentinel Network (Canada) and the Scientific Research Foundation of State Education Ministry for funding this project in the form of the Returned Overseas Chinese Scholars. The research was also supported by Shanghai Leading Academic Discipline Project (B502) and Shanghai Key Laboratory Project (08DZ2230500).

语种：英文

外文关键词：Amphoteric calixarene; Drug delivery; pH-triggered; Water-soluble

摘要：Amphoteric calix[8]arene with negatively charged upper rim and positively charged lower rim was synthesized based on water-soluble p-sulfonato-calix[8]arene. The pH-sensitive amphoteric calix[8]arenes exhibit not only a good hydrophobic drug loading capacity but also a pH-triggered drug releasing behavior. The in vitro release studies demonstrated that release of ciprofloxacin from amphoteric calix[8]arene complexes was highly pH-sensitive. More efficient drug release was observed at mildly acidic pH 5.0 and basic pH 8.5 compared to physiological pH. The amphoteric calix[8]arene complexes hold out great promise of being pH-sensitive drug carrier. (C) 2012 Elsevier B.V. All rights reserved.