文献类型：期刊文献

英文题名：Anti-Inflammatory Effects of Arsenic Trioxide Eluting Stents in a Porcine Coronary Model

作者：Shen, Li[1];Gong, Feirong[2];Tian, Wenjie[3];Li, Weiming[4];Zhang, Feng[1];Qian, Juying[1];Sun, Aijun[1];Zou, Yunzeng[1];Yang, Wei[4];Ge, Junbo[1]

机构：[1]Fudan Univ, Shanghai Inst Cardiovasc Dis, Zhongshan Hosp, Shanghai 200032, Peoples R China;[2]E China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[3]Sichuan Prov Peoples Hosp, Dept Cardiol, Chengdu 610072, Peoples R China;[4]Harbin Med Univ, Affiliated Hosp 1, Dept Cardiol, Harbin 150001, Heilongjiang, Peoples R China

年份：2013

卷号：2013

外文期刊名：BIOMED RESEARCH INTERNATIONAL

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000314958000001)】；

基金：The authors thank J. Jianguo and Y. Ruiming for their excellent technical assistance. This work is supported by National Basic Research Program of China (2011CB503905); the Science and Technology Commission of Shanghai, China (12DZ1940604) National Natural Science Foundation of China (30700318, 30870622, 81101133); and the Young Scientific "Phosphor" (Tracking) Project from the Shanghai Science and Technology Development (no. 11QH1400500).

语种：英文

摘要：Previous research from our group has demonstrated arsenic trioxide eluting stents significantly reduced neointimal area and thickness compared with bare metal stents. In the present study, the anti-inflammatory effects of arsenic trioxide in vitro and arsenic trioxide eluting stents in a porcine coronary model have been explored. Sixty-five pigs underwent placement of 139 oversized stents in the coronary arteries with histologic analysis, endothelial function analysis, and immunohistochemical and western blot analyses. Arsenic trioxide eluting stents effectively inhibited local inflammatory reactions, while no significant difference in endothelialization and endothelial function between arsenic trioxide eluting stents and bare metal stents was observed. Arsenic trioxide eluting stents favorably modulate neointimal formation due to less augmentation of early inflammatory reactions, and quick endothelialization of the stent surface, which might contribute to long-term safety and efficacy of drug eluting stents.