文献类型：期刊文献

英文题名：Enhanced antitumor efficacy of vitamin E TPGS-emulsified PLGA nanoparticles for delivery of paclitaxel

作者：Sun, Yanbin[2];Yu, Bo[3];Wang, Guoying[4];Wu, Yongsheng[5];Zhang, Xiaomin[3];Chen, Yanmin[5];Tang, Suoqing[6];Yuan, Yuan[4];Lee, Robert J.[7,8];Teng, Lesheng[1,7];Xu, Shun[2]

机构：[1]Jinlin Univ, Sch Life Sci, 2699 Qianjin Ave, Changchun, Jilin Province, Peoples R China;[2]China Med Univ, Hosp 1, Dept Thorac Surg, Shenyang, Liaoning, Peoples R China;[3]Hangzhou PushiKang Biotechnol Co Ltd, Hangzhou, Zhejiang, Peoples R China;[4]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[5]Mudanjiang Youbo Pharmaceut Co Ltd, Beijing, Peoples R China;[6]Peoples Liberat Army Gen Hosp, Dept Pediat, Beijing, Peoples R China;[7]Jinlin Univ, Sch Life Sci, Changchun, Peoples R China;[8]Ohio State Univ, Coll Pharm, Columbus, OH 43210 USA

年份：2014

卷号：123

起止页码：716

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20145000322016);WOS:【SCI-EXPANDED(收录号:WOS:000347580500088)】；

基金：This work was supported by the Chinese National 863 Project (no. 2012AA020804).

语种：英文

外文关键词：Paclitaxel; TPGS; Nanoparticles; Lung cancer; Drug delivery; Chemotherapy

摘要：Nanoparticles are efficient delivery vehicles for cancer therapy such as paclitaxel (PTX). In this study, we formulated PTX into PLGA polymeric nanoparticles. Vitamin E TPGS was used as an emulsifier to stabilize the nanoparticle formulation. PTX was encapsulated in TPGS-emulsified polymeric nanoparticles (TENPs) by a nanoprecipitation method in ethanol-water system. The resultant PTX-TENPs showed a very uniform particle size (similar to 100nm) and high drug encapsulation (>80%). The cytotoxicity of PTX-TENPs was examined in A549 lung cancer cell line. Preferential tumor accumulation of TENPs was observed in the A549 lung cancer xenograft model. Tumor growth was significantly inhibited by intravenous injection of PTX-TENPs. Our results suggested that the modified nanoprecipitation method holds great potential for the fabrication of the PTX loaded polymeric nanoparticles. TPGS can be used in the manufacture of polymeric nanoparticles for the controlled release of PTX and other anti-cancer drugs. (C) 2014 Elsevier B.V. All rights reserved.