文献类型：期刊文献

英文题名：Accelerated Recovery of Endothelium Function after Stent Implantation with the Use of a Novel Systemic Nanoparticle Curcumin

作者：Lu, Qi[1];Ye, Fang[2];Yang, Xiangjun[3];Gu, Qingqing[1];Wang, Peng[4];Zhu, Jianhua[1];Shen, Li[2];Gong, Feirong[5]

机构：[1]Nantong Univ, Affiliated Hosp, Dept Cardiol, Nantong 226001, Peoples R China;[2]Fudan Univ, Zhongshan Hosp, Dept Radiol, Shanghai 200032, Peoples R China;[3]Suzhou Univ, Affiliated Peoples Hosp 1, Dept Cardiol, Suzhou 215006, Peoples R China;[4]Suzhou Univ, Affiliated Peoples Hosp 1, Dept Electrocardiogram, Suzhou 215006, Peoples R China;[5]E China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China

年份：2015

卷号：2015

外文期刊名：BIOMED RESEARCH INTERNATIONAL

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000356682600001)】；

基金：This work was supported by the National Natural Science Foundation of China (no. 81370323), Jiangsu Province's Outstanding Medical Leader Program (no. LJ201140), and National Basic Research Program ("973" Program) of China (no. 2011CB503905).

语种：英文

摘要：Curcumin was reported to exhibit a wide range of pharmacological effects including antioxidant, anti-inflammatory, and antiproliferative activities and significantly prevent smooth muscle cells migration. In the present study, a novel kind of curcumin loaded nanoparticles (Cur-NP) has been prepared and characterized with the aim of inhibiting inflammation formation and accelerating the healing process of the stented arteries. Cur-NP was administrated intravenously after stent implantation twice a week and detailed tissue responses were evaluated. The results demonstrated that intravenous administration of Cur-NP after stent implantation accelerated endothelial cells restoration and endothelium function recovery and may potentially be an effective therapeutic alternative to reduce adverse events for currently available drug eluting stents.