文献类型：期刊文献

英文题名：Synthesis, self-assembly and pH sensitivity of PDEAEMA-PEG-PDEAEMA triblock copolymer micelles for drug delivery

作者：Wang, Guiyou[1];Zhang, Lingmei[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Shanghai 200237, Peoples R China

年份：2016

卷号：107

起止页码：1

外文期刊名：REACTIVE & FUNCTIONAL POLYMERS

收录：;EI(收录号：20163202694092);WOS:【SCI-EXPANDED(收录号:WOS:000385598100001)】；

基金：This study was supported by Shanghai Branch, Du Pont China Co. Ltd. The authors wish to thank Associate Prof. Hongli Zhao, Associate Prof. Yun Ding and Prof. Aiguo Hu for their kind assistance.

语种：英文

外文关键词：ATRP; Triblock copolymers; pH-sensitive micelles; Biocompatibility; Drug delivery

摘要：In this study, well-defined double-hydrophilic triblock copolymers, consisting of hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(N,N-diethylamino-2-ethylmethacrylate) (PDEAEMA), were synthesized and characterized. The molecular weights of the copolymers were controllable. In the basic environments, the copolymers can self-assemble into the PDEAEMA core and PEG corona micelles in aqueous solution with an average size of 40-180 nm. The low critical micelle concentration (CMC, about 10(-3) mg mL(-1)) of copolymers investigated in pH 7.4 aqueous solution confirmed the adequate thermodynamic stability of their self-assembly. As shown in the cytotoxicity assay, the copolymers have good biocompatibility. Doxorubicin (DOX) was encapsulated into the triblock copolymer micelles. The drug loading efficiency and entrapment efficiency values of DOX-loaded micelles reached 8.14% and 88.6%, respectively. The DOX release of the drug-loaded micelles depends on the pH values. These phenomena indicated that the double-hydrophilic PDEAEMA-PEG-PDEAEMA triblock copolymers have a potential application in the drug delivery. (C) 2016 Elsevier B.V. All rights reserved.