文献类型：期刊文献

中文题名：316L不锈钢支架表面药物涂层的初步研究

英文题名：Preliminary Study of Taxol-Containing Polymer Coatings on316L Stainless Steel Stent

作者：袁媛[1];余璐[1];马元辉[1];刘昌胜[1];谢小波[2];朱瑞瑞[2]

机构：[1]华东理工大学生物材料研究所,上海200237;[2]华东理工大学分析测试中心

年份：2005

卷号：31

期号：3

起止页码：382

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;EI(收录号：2005289209202);Scopus;北大核心:【北大核心2004】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：不锈钢支架;紫杉醇;聚乙烯-乙烯醇;聚乙烯-醋酸乙烯酯;聚乳酸-乙交酯

外文关键词：stainless steel stent; taxol; plyethylene-vinyl alcohol; polyethylene-vinyl acetate; (polylactic) co-glycolid acid

摘要：高分子材料是影响316L不锈钢支架表面药物涂层性能的一个重要因素。以紫杉醇作为药物模型、以常用的3种医用高分子材料聚乙烯-乙烯醇(EVAL)、聚乙烯-醋酸乙烯酯(EVA)和聚乳酸-乙交酯(PLGA)为涂层聚合物。对316L不锈钢支架表面EVAL、EVA和PLGA涂层的综合性能(包括涂层在基体表面的结合强度、药物在涂层中的溶解扩散性能、涂层的力学性能以及表面自由能和亲水性等)进行了详细的比较、研究。结果发现:选择EVA作为底层和药物层的材料比较合适,而PLGA是制备最外层涂层的理想材料。
The quality of drug controlled-releasing coating (including three layers, the base coating, the drug matrix coating, the top coating) on the 316L stainless steel was influenced by many determinants. Among them, the polymer was the primarily important factor. In this paper, the taxol was used as model drug, polyethylene-vinyl alcohol (EVAL), polyethylene-vinyl acetate (EVA), polylactic co-glycolid acid (PLGA), which were widely applied as biomedical materials, were applied as coating polymers. The comprehensive characteristics of EVAL, EVA, PLGA coatings on stainless steel stents were investigated in details, including the bonding strength of the coatings, the drug solubility, drug diffusion coefficient, stress and tension of the coatings, surface free energy and surface hydrophilicity. The results indicate that EVA is an ideal material as base and drug matrix coating, whereas PLGA is a suitable material for the top coating.