文献类型：期刊文献

英文题名：Hematopoietic reconstitution of CD34+ cells grown in static and stirred culture systems in NOD/SCID mice

作者：Yang, Shi[1]; Cai, Haibo[1]; Jin, Huili[1]; Tan, Wen-Song[1]

机构：[1] State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China

年份：2008

卷号：30

期号：1

起止页码：61

外文期刊名：Biotechnology Letters

收录：EI(收录号：20074910966210)

语种：英文

外文关键词：Biotechnology - Cell culture - Grafting (chemical) - Rats

摘要：The hematopoietic reconstitution of cord blood (CB) CD34+ cells grown in static and stirred system was studied. Static cultures were better than stirred cultures for cell expansion. Engraftment of stirred-culture hematopoietic stem cells (HSCs) was higher than static-culture HSCs. Stirred-culture HSCs had better multilineage reconstitution ability and colony-forming ability than static-culture HSCs. Static cultures thus favor the expansion of HSCs and stirred cultures are more effective in preserving functional HSCs. ? 2007 Springer Science+Business Media B.V.