文献类型：期刊文献

英文题名：Highly Antibacterial and Adhesive Hyaluronic Acid Hydrogel for Wound Repair

作者：Huang, Baoxuan[1];Hu, Dan[1];Dong, Alideertu[2];Tian, Jia[1];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]Inner Mongolia Univ, Coll Chem & Chem Engn, Hohhot 010021, Peoples R China

年份：2022

卷号：23

期号：11

起止页码：4766

外文期刊名：BIOMACROMOLECULES

收录：;EI(收录号：20224613106202);WOS:【SCI-EXPANDED(收录号:WOS:000884983000001)】；

基金：The authors acknowledge the financial support from the National Natural Science Foundation of China (Nos. 21875063, 22075079, and 52203009), the Science and Technology Commission of Shanghai Municipality for the Shanghai International Cooperation Program (No. 21520713400), Natural Science Foundation of Shanghai (No. 21ZR1417800), and the Fundamental Research Funds for the Central Universities (No. JKJ01221113).

语种：英文

外文关键词：Adhesives - Amines - Biocompatibility - Biodegradability - Crosslinking - Health hazards - Hyaluronic acid - Mammals - Organic acids - Photosensitizers - Repair

摘要：Bacterial infections accompanied with wound healing often lead to more serious health hazards to patients. Therefore, it is urgent to explore a wound dressing that can promote wound repair while possessing antibacterial capability. Here, we constructed a multifunctional hydrogel dressing by a redox-initiated cross-linking reaction of methacrylated hyaluronic acid (HAMA), 5,10,15,20-tetra (4-methacrylate phenyl) porphyrin (TPP), and dopamine methacrylamide (DMA), named HAMA-TPP-DMA, with broad-spectrum photodynamic antibacterial capability, where the aggregation of TPP photosensitizer units could be greatly inhibited to produce more singlet oxygen. The hydrogel has excellent biodegradability and biocompatibility, providing favorable conditions for wound healing. Furthermore, the incorporation of dopamine into the hydrogel gives the wound dressing with enhanced adhesiveness, benefiting for the wound repair. More importantly, the antibacterial experiments in vitro and mice wound models in vivo showed that the HAMA-TPP-DMA hydrogel can significantly resist bacteria and accelerate the wound healing in mice (the closure rate > 98% after 15 days). Thus, this hydrogel dressing with superior antibacterial infection and wound healing capability provides a promising strategy in wound repair.