文献类型：期刊文献

英文题名：Application of Antibiotics/Antimicrobial Agents on Dental Caries

作者：Qiu, Wei[1,2];Zhou, Yujie[2,3];Li, Zixin[4];Huang, Tu[4];Xiao, Yuhan[4];Cheng, Lei[2];Peng, Xian[2];Zhang, Lixin[5,6];Ren, Biao[2]

机构：[1]Southern Med Univ, Nanfang Hosp, Dept Stomatol, Guangzhou 510515, Peoples R China;[2]Sichuan Univ, State Key Lab Oral Dis, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Chengdu 610064, Peoples R China;[3]Sichuan Univ, Dept Operat Dent & Endodont, West China Hosp Stomatol, Chengdu 610041, Peoples R China;[4]Sichuan Univ, West China Sch Stomatol, Chengdu 610041, Peoples R China;[5]Chinese Acad Sci, Key Lab Pathogen Microbiol & Immunol, Inst Microbiol, Beijing 100101, Peoples R China;[6]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2020

卷号：2020

外文期刊名：BIOMED RESEARCH INTERNATIONAL

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000514386900018)】；

基金：This work was supported by grants from National Natural Science Foundation of China (81600858), Scientific Research Starting Foundation for Young Teachers of Sichuan University (2015SCU11015), and State Key Laboratory of Oral Diseases (SKLOD201526).

语种：英文

摘要：Dental caries is the most common oral disease. The bacteriological aetiology of dental caries promotes the use of antibiotics or antimicrobial agents to prevent this type of oral infectious disease. Antibiotics have been developed for more than 80 years since Fleming discovered penicillin in 1928, and systemic antibiotics have been used to treat dental caries for a long time. However, new types of antimicrobial agents have been developed to fight against dental caries. The purpose of this review is to focus on the application of systemic antibiotics and other antimicrobial agents with respect to their clinical use to date, including the history of their development, and their side effects, uses, structure types, and molecular mechanisms to promote a better understanding of the importance of microbial interactions in dental plaque and combinational treatments.