文献类型：期刊文献

英文题名：High-Linearity Hydrogel-Based Capacitive Sensor Based on Con A-Sugar Affinity and Low-Melting-Point Metal

作者：Yin, Ruixue[1];Xin, Jizhong[1];Yang, Dasheng[1];Gao, Yang[1,2];Zhang, Hongbo[1];Qian, Zhiqin[1];Zhang, Wenjun[3]

机构：[1]East China Univ Sci & Technol, Sch Mech & Power Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Intelligent Sensing & Detect Tec, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Univ Saskatchewan, Div Biomed Engn, 57 Campus Dr, Saskatoon, SK S7N 5A9, Canada

年份：2022

卷号：14

期号：20

外文期刊名：POLYMERS

收录：;EI(收录号：20224413044051);WOS:【SCI-EXPANDED(收录号:WOS:000873587200001)】；

基金：The authors would like to gratefully acknowledge the financial support by the Shanghai Science and Technology Innovation Program (No. 19441909600), the Opening Project of Shanghai Key Laboratory of Orthopedic Implants (KFKT2019001), and the National Natural Science Foundation of China (Grant No. 52275146, 21404038).

语种：英文

外文关键词：hydrogel; glucose capacitive sensor; low-melting-point metal; serpentine electrodes; continuous glucose monitoring system

摘要：Continuous glucose monitoring (CGM) plays an important role in the treatment of diabetes. Affinity sensing based on the principle of reversible binding to glucose does not produce intermediates, and the specificity of concanavalin A (Con A) to glucose molecules helps to improve the anti-interference performance and long-term stability of CGM sensors. However, these affinity glucose sensors have some limitations in their linearity with a large detection range, and stable attachment of hydrogels to sensor electrodes is also challenging. In this study, a capacitive glucose sensor with high linearity and a wide detection range was proposed based on a glucose-responsive DexG-Con A hydrogel and a serpentine coplanar electrode made from a low-melting-point metal. The results show that within the glucose concentration range of 0-20 mM, the sensor can achieve high linearity (R-2 = 0.94), with a sensitivity of 33.3 pF mM(-1), and even with the larger glucose concentration range of 0-30 mM the sensor can achieve good linearity (R-2 = 0.84). The sensor also shows resistance to disturbances of small molecules, good reversibility, and long-term stability. Due to its low cost, wide detection range, high linearity, good sensitivity, and biocompatibility, the sensor is expected to be used in the field of continuous monitoring of blood glucose.