文献类型：期刊文献

中文题名：Spectral and biodistributional engineering of deep near-infrared chromophore

作者：Yan Dong[1];Xicun Lu[1];Yi Li[1];Weichao Chen[1];Lei Yin[1];Jie Zhao[1];Xinru Hu[1];Xinran Li[1];Zuhai Lei[1];Yuyang Wu[3];Hao Chen[3];Xiao Luo[1,2];Xuhong Qian[1,2];Youjun Yang[1]

机构：[1]State Key Laboratory of Bioreactor Engineering,Shanghai Key Laboratory of Chemical Biology,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China;[2]Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development,School of Chemistry and Molecular Engineering,East China Normal University,Shanghai 200241,China;[3]Molecular Imaging Center,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China

年份：2023

卷号：34

期号：9

起止页码：176

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2023_2024】；PubMed;

基金：supported by the National Natural Science Foundation of China(Nos.21908065,22078098,and 22278138);the Shanghai Academic Technology Research Leader(No.22XD1421000);the Research Funds of Happiness Flower ECNU(No.2020JK2103);the Open Funding Project of the State Key Laboratory of Bioreactor Engineering。

语种：英文

中文关键词：Near infrared fluorophore;In vivo imaging;Molecular engineering;Biological distribution;Angiography

摘要：Fluorescence-guided surgery calls for development of near-infrared fluorophores.Despite the wide-spread application and a safe clinical record of Indocyanine Green(ICG),its maximal absorption wavelength at780 nm is rather short and longer-wavelength dyes are desired to exploit such benefits as low phototoxicity and deep penetration depth.Here,we report ECY,a stable deep near-infrared(NIR)fluorochromic scaffold absorbing/emitting at 836/871 nm with a fluorescence quantum yield of 16%in CH_(2)Cl_(2).ECY was further rationally engineered for biological distribution specificity.Analogous bearing different numbers of sulfonate group or a polyethylene glycol chain were synthesized.By screening this focused library upon intravenous injection to BALB/c mice,ECYS2 was identified to be a suitable candidate for bioimaging of organs involved in hepatobiliary excretion,and ECYPEG was found to be a superior candidate for vasculature imaging.They have potentials in intraoperative imaging.