文献类型：期刊文献

英文题名：Cinchona Alkaloid Squaramide Catalyzed Enantioselective Hydrazination/Cyclization Cascade Reaction of α-Isocyanoacetates and Azodicarboxylates: Synthesis of Optically Active 1,2,4-Triazolines

作者：Zhao, Mei-Xin[1,2,3];Bi, Hong-Lei[1,2];Zhou, Hao[1,2];Yang, Hui[1,2];Shi, Min[1,2,4]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China;[4]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

年份：2013

卷号：78

期号：18

起止页码：9377

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20134016795868);WOS:【SCI-EXPANDED(收录号:WOS:000330159500047)，CCR-EXPANDED(收录号:WOS:000330159500047)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (20772030, 21072056, 21272067), the Fundamental Research Funds for the Central Universities, Scientific Research Foundation for the Returned Overseas Chinese Scholars, and State Education Ministry.

语种：英文

外文关键词：Alkaloids - Hydrazine - Catalysis - Metabolites

摘要：An efficient enantioselective hydrazination/cyclization cascade reaction of alpha-substituted isocyanoacetates to azodicarboxylates catalyzed by Cinchona alkaloid derived squaramide catalysts has been investigated, affording the optically active 1,2,4-triazolines in excellent yields (up to 99%) and good to excellent enantioselectivities (up to 97% ee) under mild conditions.