文献类型：期刊文献

英文题名：One-pot fabrication of a polydopamine-based nanoplatform for GSH triggered trimodal ROS-amplification for cancer therapy

作者：Wang, Qinghua[1];Jia, Xinlin[2];Li, Xianglong[1];He, Miao[1];Hao, Ji-Na[1];Guan, Mengjia[1];Mao, Yuanqing[2];Cao, Yuanyuan[1];Bin Dai[3];Li, Yongsheng[1,3]

机构：[1]East China Univ Sci & Technol, Frontier Sci Ctr Mat Biol & Dynam Chem, Shanghai Engn Res Ctr Hierarch Nanomat,Lab Low Di, Key Lab Ultrafine Mat,Minist Educ,Sch Mat Sci & E, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Orthopaed Surg, Shanghai Key Lab Orthopaed Implants,Sch Med, Shanghai 200011, Peoples R China;[3]Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832003, Peoples R China

年份：2022

卷号：10

期号：15

起止页码：4208

外文期刊名：BIOMATERIALS SCIENCE

收录：;EI(收录号：20222612297103);WOS:【SCI-EXPANDED(收录号:WOS:000814534800001)】；

基金：The authors acknowledge the financial support from the National Natural Science Foundation of China (No. 51621002, 51972112, 22005096), the Basic Research Program of Shanghai Municipal Government (Grant No. 21JC1406000, 19JC1411700), the Shanghai Sailing Program (20YF1410100), the Leading Talents in Shanghai in 2018 and the 111 Project (B14018). All animal experiments were performed in compliance with the Guidelines for the Care and Use of Research Animals established by the East China University of Science and Technology Animal Studies.

语种：英文

外文关键词：Antioxidants - Cell death - Controlled drug delivery - Copper - Diseases - Fabrication - Heavy ions - Medical nanotechnology - Metal ions - Oxidation - Targeted drug delivery

摘要：Reactive oxygen species (ROS) based nanoplatforms have been considered as attractive and feasible candidates for cancer therapy. However, the activated endogenous antioxidant defense of cancer cells in response to the ROS attack greatly hinders their therapeutic efficacy. Although cancer-specific ROS amplification strategies have been widely explored, most of them suffer from tedious synthesis procedures and complex components, which will bring about undesired side effects and unsatisfactory results. Herein, we design a cancer-specific oxidative stress amplification nanomedicine (CA-Cu-PDA), which is simply fabricated through integrating the glutathione (GSH) responsive/depleting nanocarrier of copper-polydopamine (Cu-PDA) nanoparticles with a ROS-generating drug cinnamaldehyde (CA) via a facile one-pot polymerization route. It is verified that GSH could trigger the breakage of CA-Cu-PDA networks and the subsequent release of both copper ions and CA in cancer cells. The released copper ions efficiently oxidize GSH, thereby weakening the antioxidant system of cancer cells and increasing the ROS levels. On the other hand, extra ROS are generated by the reduced copper ions through a Fenton reaction, so that a synergistic ROS therapy with CA is achieved. Consequently, oxidative stress is specifically increased within cancer cells, leading to efficient cancer cell apoptosis, significant tumor suppression and minimized side effects. Such an ingenious structure realizes the interlocking cooperation and full utilization of each component's function, presenting promising perspectives for nanomedicine design.