文献类型：期刊文献

英文题名：Ligand-Enabled Pd-Catalyzed Enantioselective C-H Amination for the Synthesis of Axially Chiral Biaryl Diamines

作者：Cen, Shouyi[1,2];Shen, Ahui[1,2];Dai, Ji-Ye[1,2];Ju, Chenxi[1,2];Li, Zhuoqun[1,2];Zhang, Zhipeng[1,2,3]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Key Lab Adv Mat, Shanghai, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Joint Int Res Lab Precis Chem, Shanghai, Peoples R China;[3]Weifang Univ, Sch Chem & Chem Engn & Environm Engn, Weifang, Peoples R China

年份：2026

外文期刊名：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001768649200001)】；

基金：This study was supported by National Natural Science Foundation of China (22371072, 22571082, 22501081), Natural Science Foundation of Shanghai Municipality (24ZR1415000), Fundamental Research Funds for the Central Universities (222201717003, JKVJ1251010, SLJ13233303 and YJ0142232), Science and Technology Commission of Shanghai Municipality (24DX1400200), Program of Introducing Talents of Discipline to Universities (B16017).

语种：英文

外文关键词：axially chiral; biaryl diamines; BINAM; C-H amination; enantioselectivity

摘要：Pd-catalyzed enantioselective C-H amination of biaryl amines with morpholino benzoate has been achieved using a novel class of axially chiral diamine ligands featuring a binaphthyl skeleton. The reaction proceeds under very mild conditions and exhibits good functional group tolerance, delivering a range of axially chiral biaryl diamine derivatives bearing a morpholine unit in moderate to good yields (up to 79%) and with good enantioselectivity (up to 90.5:9.5 enantiomeric ratio (er)).