文献类型：期刊文献

英文题名：Penfluridol targets septin7 to suppress endometrial cancer by septin7-Orai/IP3R Ca2+-PIK3CA pathway-

作者：Song, Lingyi[1];Wu, Huiwen[1];Sun, Xiao[2];Liu, Xiaohu[1];Ling, Xianwu[1];Ni, Wei[1];Li, Lijuan[2];Liu, Beibei[1];Wei, Jinlian[1];Li, Xiaokang[1];Li, Jian[1,3,4];Wang, Yudong[2,5];Mao, Fei[1]

机构：[1]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Pharm,Shanghai Key Lab New Drug Design,State K, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Int Peace Matern & Child Hlth Hosp, Sch Med, Dept Gynecol Oncol, Shanghai 200030, Peoples R China;[3]Shihezi Univ, Sch Pharm, Key Lab Xinjiang Phytomed Resource & Utilizat, Minist Educ, Shihezi 832003, Peoples R China;[4]Hainan Univ, Coll Pharm, Key Lab Trop Biol Resources, Minist Educ, Haikou 570228, Peoples R China;[5]Shanghai Municipal Key Clin Specialty, Female Tumor Reprod Specialty, Shanghai 200030, Peoples R China

年份：2025

卷号：28

期号：1

外文期刊名：ISCIENCE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001398713800001)】；

语种：英文

摘要：Phenotypic screening of existing drugs is a good strategy to discover new drugs. Herein, 33 psychotherapeutic drugs in our drug library were screened by phenotypic screening and penfluridol (PFD) was found to exhibit excellent anti-endometrial cancer (EC) activity both in vitro and in vivo. Furthermore, the molecular target of PFD was identified as septin7, a tumor suppressor in EC. In septin7-deficient EC cells and xenograft mouse models, PFD exhibited weaker anti-cancer properties, indicating that septin7 was essential for the tumor inhibitory activity. Notably, PFD could induce cell apoptosis by regulating the septin7-Orai/IP3RCa2+-PIK3CA pathway. In addition, PFD attenuates the interaction of septin7-tubulin, thereby inhibiting microtubule polymerization. In summary, this study revealed a target and mechanistic insights into EC therapeutic strategies and identified a potential candidate agent for the treatment of EC.