文献类型：期刊文献

英文题名：Engineering an Organic Nanoplatform for Augmented Pyroeletroimmunotherapy

作者：Li, Xingguang[1];Gao, Meng-Lu[1];Wang, Shan-Shan[1];Li, Yu-Long[1];Liu, Tong-Ning[1];Xiang, Huijing[2];Liu, Pei-Nian[1,3]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China;[3]China Pharmaceut Univ, Dept Med Chem, State Key Lab Nat Med, Nanjing 211198, Peoples R China

年份：2024

卷号：36

期号：32

外文期刊名：ADVANCED MATERIALS

收录：;EI(收录号：20242316221447);WOS:【SCI-EXPANDED(收录号:WOS:001241581800001)】；

基金：X.L. and M.-L.G. contributed equally to this work. The authors acknowledged the financial aid from the National Natural Science Foundation of China (Nos. 22201073, 21925201, 22161160319, T2322018, and 32171391), Shanghai Rising-Star Program (No. 22QA1403600) and the Fundamental Research Funds for the Central Universities. All the animal studies were approved by the Committee on the Ethics of Animal Experiments of Shanghai University (Approval No. ECSHU 2021-050). The authors thanked the Research Center of Analysis and Testing of East China University of Science and Technology for help in the characterization.

语种：英文

外文关键词：immunogenic cell death; nanomedicine; organic pyroelectric nanoplatform; pyroelectroimmunotherapy; tumor therapy

摘要：Photothermal immunotherapy has shown great promise in the treatment of tumor metastasis. However, the thermal resistance of tumor cells substantially compromises the treatment effect of photothermal immunotherapy. Herein, a high-performance organic pyroelectric nanoplatform, tBu-TPAD-BF2 nanoparticles (NPs), is rationally engineered for the effective pyroelectroimmunotherapy of tumor metastasis. Biocompatible tBu-TPAD-BF2 NPs with excellent pyroelectric and photothermal conversion properties are constructed by assembling organic, low-bandgap pyroelectric molecules with amphiphilic polymers. After internalization by tumor cells, treatment with tBu-TPAD-BF2 NPs causes an apparent temperature elevation upon near-infrared (NIR) laser irradiation, inducing potent immunogenic cell death (ICD). Additionally, the temperature variations under alternating NIR laser irradiation facilitate reactive oxygen species production for pyroelectric therapy, thus promoting ICD activation and lowering thermal resistance. Importantly, in vivo assessments illustrate that tBu-TPAD-BF2 NPs in combination with NIR laser exposure notably inhibit primary and distant tumor proliferation and prominently retarded lung metastasis. RNA profiling reveals that treatment with tBu-TPAD-BF2 NPs markedly suppresses metastasis under NIR laser illumination by downregulating metastasis-related genes and upregulating immune response-associated pathways. Therefore, this study provides a strategy for designing high-performance pyroelectric nanoplatforms to effectively cure tumor metastasis, thereby overcoming the inherent shortcomings of photothermal immunotherapy. A high-performance organic nanoplatform, tBu-TPAD-BF2 NPs, is rationally engineered for the effective pyroelectroimmunotherapy of tumor metastasis. In vivo assessments reveal that tBu-TPAD-BF2 NPs and NIR laser exposure significantly inhibit the proliferation of primary and distant tumors and prominently retarded lung metastasis. This study provides a strategy for designing organic pyroelectric nanoplatforms to effectively cure tumor metastasis and overcome the inherent shortcomings of photothermal immunotherapy. image