文献类型：期刊文献

英文题名：Improved osteogenesis and angiogenesis of magnesium-doped calcium phosphate cement via macrophage immunomodulation

作者：Wang, Meng[1,2];Yu, Yuanman[1,2];Dai, Kai[1,2];Ma, Zhengyu[1,2];Liu, Yang[1,2];Wang, Jing[1,2];Liu, Changsheng[1,2,3]

机构：[1]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2016

卷号：4

期号：11

起止页码：1574

外文期刊名：BIOMATERIALS SCIENCE

收录：;EI(收录号：20164302943216);WOS:【SCI-EXPANDED(收录号:WOS:000386219300004)】；

基金：The authors wish to express their gratitude for the financial support from the National Natural Science Foundation of China (no. 31330028, no. 31470923, and no. 31271011), the National Basic Research Program of China (973 Program, no. 2012CB933600), the Major Basic Research Foundation of Shanghai Science and Technique Committee (14JC1490800), and the Shanghai International Incorporation Program (155207111000). This study is also supported by the New Century Excellent Talents in University (no. NCET-12-0856) and the 111 Project (B14018).

语种：英文

外文关键词：Bone - Repair - Immune system - Tissue regeneration - Calcium phosphate - Magnesium compounds - Cements

摘要：Immune responses are vital for bone regeneration and play an essential role in the fate of biomaterials after implantation. As a kind of plastic cell, macrophages are central regulators of the immune response during the infection and wound healing process including osteogenesis and angiogenesis. Magnesium-calcium phosphate cement ( MCPC) has been reported as a promising candidate for bone repair with promoted osteogenesis both in vitro and in vivo. However, relatively little is known about the effects of MCPC on immune response and the following outcome. In this study, we investigated the interactions between macrophages and MCPC. Here we found that the pro-inflammatory cytokines including TNF-alpha and IL-6 were less expressed and the bone repair related cytokine of TGF-beta 1 was up-regulated by macrophages in MCPC extract. Furthermore, the enhanced osteogenic capacity of BMSCs and angiogenic potential of HUVECs were acquired in vitro by the MCPC-induced immune microenvironment. These findings suggest that MCPC is able to facilitate bone healing by endowing favorable osteoimmunomodulatory properties and influencing crosstalk behavior between immune cells and osteogenesis-related cells.