文献类型：期刊文献

英文题名：A Senomorphlytic Three-Drug Combination Discovered in Salsola collina for Delaying Aging Phenotypes and Extending Healthspan

作者：Wang, Jiqun[1];Liu, Wenwen[2];Huang, Yunyuan[3];Wang, Guangwei[4];Guo, Xiaobo[1];Shi, Donglei[2];Sun, Tianyue[1];Xiao, Chaojiang[5,6];Zhang, Chao[1];Jiang, Bei[5,6];Guo, Yuan[4];Li, Jian[1,2,7]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Pharm, Shanghai Key Lab New Drug Design,State Key Lab Bio, Shanghai 200237, Peoples R China;[2]Hainan Univ, Sch Pharmaceut Sci, Key Lab Trop Biol Resources, Minist Educ, Haikou 570228, Peoples R China;[3]Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China;[4]Northwest Univ, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol, Minist Educ, Xian 710127, Peoples R China;[5]Dali Univ, Inst Mat Med, Yunnan Key Lab Screening & Res Antipathogen Plant, Dali 671000, Yunnan, Peoples R China;[6]Dali Univ, Coll Pharm, Dali 671000, Yunnan, Peoples R China;[7]Shihezi Univ, Sch Pharm, Key Lab Xinjiang Phytomed Resource & Utilizat, Minist Educ, Shihezi 832003, Peoples R China

年份：2024

卷号：11

期号：36

外文期刊名：ADVANCED SCIENCE

收录：;EI(收录号：20243116798399);WOS:【SCI-EXPANDED(收录号:WOS:001279815400001)】；

基金：The authors gratefully appreciate the financial support from the National Natural Science Foundation of China (grants 22037002 to J.L. and Y.G., 21977082 to Y.G., 32121005 to J.L., 82104068 to Y.Y.H. and 22207026 to W.W.L.), the Innovation Program of Shanghai Municipal Education Commission (grant 2021-01-07-00-02-E00104 to J.L.), the Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism (grant 2021 Sci & Tech 03-28 to J.L.), the Innovative Research Team of High-level Local Universities in Shanghai (grant SHSMU-ZDCX20212702 to J.L.) and the Chinese Special Fund for State Key Laboratory of Bioreactor Engineering (2060204 to J.L.). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.

语种：英文

外文关键词：anti-aging drugs; combination drugs; salsola collina; senomorphlytic activity

摘要：The pursuit of pharmacological interventions in aging aims focuses on maximizing safety and efficacy, prompting an exploration of natural products endowed with inherent medicinal properties. Subsequently, this work establishes a unique library of plant extracts sourced from Yunnan Province, China. Screening of this herbal library herein revealed that Salsola collina (JM10001) notably enhances both lifespan and healthspan in C. elegans. Further analysis via network pharmacology indicates that the p53 signaling pathway plays a crucial role in mediating the anti-aging effects of JM10001. Additionally, this work identifies that a composition, designated as JM10101 and comprising three chemical constituents of JM10001, preserves the original lifespan-extending activity in C. elegans. Both JM10001 and JM10101 mitigate aging symptoms in senescence-accelerated mice treated with doxorubicin and in naturally aged mice. Notably, JM10101 exhibits a more sophisticated senomorphlytic role encompassing both senomorphic and senolytic functions than JM10001 in the modulation of senescent cells, offering a promising strategy for the discovery of combination drugs in the rational development of anti-aging therapies.