文献类型：期刊文献

英文题名：ROS-responsive selenium-containing polyphosphoester nanogels for activated anticancer drug release

作者：Zhang, Yan[1];Ma, Chuan[1];Zhang, Sihang[2];Wei, Chao[1];Xu, Ying[1];Lu, Wei[2]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Shanghai Key Lab Adv Polymer Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Fudan Univ, Sch Pharm, Dept Pharmaceut, Key Lab Smart Drug Delivery,Minist Educ,State Key, Shanghai 200433, Peoples R China

年份：2018

卷号：9

起止页码：34

外文期刊名：MATERIALS TODAY CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000444516700004)】；

基金：This work was partially supported by National Natural Science Foundation of China (81673018), Shanghai Natural Science Foundation (17ZR1407100), School of Pharmacy, Fudan University & The Open Project Program of Key Lab of Smart Drug Delivery (Fudan University, SDD2017-04), Ministry of Education and 111 Project (B14018), the award of the "National Youth Thousand Talents Plan" of China, the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning (No. 2012-05).

语种：英文

外文关键词：Nanogel; Selenium-containing; Polyphosphoester; Oxidation-responsive; Intracellular drug release

摘要：Nowadays, the stability and on-demand release of drug carriers are still to be solved. To meet the demand of these issues, we developed a reactive oxygen species (ROS) responsive selenium-containing polyphosphoesters nanogel (PSeP) by a facile one-step ring-opening polymerization of the novel monomer 4-selenoctane-1,8-diyl bis(propylphosphatelane) (Se-COP) with polyethylene glycol (mPEG) employed as the macroinitiator. Their structure was confirmed by NMR, FT-IR and GPC. The crosslinked core-shell structure imparted the nanogels with excellent dimensional stability according to the dynamic light scattering (DLS) and transmission electron microscopy (TEM). Moreover, the selenide groups endowed the nanogels with rich ROS responsiveness when subjected to the stimuli of H2O2, thus the drug-loaded PSeP nanogels displayed swollen behaviors leading to an activated doxorubicin hydrochloride (DOX $ HCl) release. The release mechanisms fitted by the Ritger-Peppas power-law model also proved the swollen release process. MTT assays exhibited that the PSeP nanogels were nontoxic up to a tested concentration of 50 mu g mL(-1) by A549 and HEK293, and the DOX-loaded PSeP had a high anticancer behaviour against A549 cancer cells. Additionally, these nanogels possessed enhanced intracellular drug release by CLSM. Therefore, these results highlighted that the selenium-containing polyphosphoesters nanogels could be a potential platform for the ROS-sensitive drug delivery. (C) 2018 Published by Elsevier Ltd.