文献类型：期刊文献

英文题名：Real-Time Direct Monitoring of Chirality Fixation and Recognition at the Single-Molecule Level

作者：Hu, Weilin[1];Li, Mingyao[1];Xiong, Wan[2,3];Zhou, Shuyao[1];Zou, Qi[4,5];Lu, Jing-Tao[2,3];Tian, He[4,5];Guo, Xuefeng[1,6]

机构：[1]Peking Univ, Coll Chem & Mol Engn, Natl Biomed Imaging Ctr, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China;[2]Huazhong Univ Sci & Technol, Inst Quantum Sci & Engn, Sch Phys, Wuhan 430074, Peoples R China;[3]Huazhong Univ Sci & Technol, Wuhan Natl High Magnet Field Ctr, Wuhan 430074, Peoples R China;[4]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[5]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[6]Nankai Univ, Coll Elect Informat & Opt Engn, Frontiers Sci Ctr New Organ Matter, Ctr Single Mol Sci,Inst Modern Opt, Tianjin 300350, Peoples R China

年份：2024

卷号：146

期号：26

起止页码：17765

外文期刊名：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

收录：;EI(收录号：20242616349404);WOS:【SCI-EXPANDED(收录号:WOS:001264129900001)】；

基金：We acknowledge primary financial supports from the National Key R&D Program of China (2021YFA1200101 and 2022YFE0128700), the National Natural Science Foundation of China (22150013, 21933001, 22335004, and 22175064), the New Cornerstone Science Foundation through the XPLORER PRIZE, "Frontiers Science Center for New Organic Matter" at Nankai University (63181206), and the Natural Science Foundation of Beijing (2222009).

语种：英文

外文关键词：Amines - Graphene - Molecules - Stereochemistry

摘要：Chirality, a fundamental attribute of nature, significantly influences a wide range of phenomena related to physical properties, chemical reactions, biological pharmacology, and so on. As a pivotal aspect of chirality research, chirality recognition contributes to the synthesis of complex chiral products from simple chiral compounds and exhibits intricate interplay between chiral materials. However, macroscopic detection technologies cannot unveil the dynamic process and intrinsic mechanisms of single-molecule chirality recognition. Herein, we present a single-molecule detection platform based on graphene-molecule-graphene single-molecule junctions to measure the chirality recognition involving interactions between amines and chiral alcohols. This approach leads to the realization of in situ and real-time direct observation of chirality recognition at the single-molecule level, demonstrating that chiral alcohols exhibit compelling potential to induce the formation of the corresponding chiral configuration of molecules. The amalgamation of theoretical analyses with experimental findings reveals a synergistic action between electrostatic interactions and steric hindrance effects in the chirality recognition process, thus substantiating the microscopic mechanism governing the chiral structure-activity relationship. These studies open up a pathway for exploring novel chiral phenomena from the fundamental limits of chemistry, such as chiral origin and chiral amplification, and offer important insights into the precise synthesis of chiral materials.