文献类型：期刊文献

英文题名：Harnessing Hypoxia-Dependent Cyanine Photocages for In Vivo Precision Drug Release

作者：Zhang, Yutao[1,2];Yan, Chenxu[1,2];Zheng, Qiaoqiao[3];Jia, Qian[4];Wang, Zhongliang[4];Shi, Ping[3];Guo, Zhiqian[1,2,3]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Mat & Dynam Chem, Key Lab Adv Mat, Feringa Nobel Prize Scientist Joint Res Ctr,Sch C, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Mat & Dynam Chem, Inst Fine Chem, Feringa Nobel Prize Scientist Joint Res Ctr,Sch C, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[4]Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol Imaging & Neuroimaging, Xian 710126, Shaanxi, Peoples R China

年份：2021

卷号：60

期号：17

起止页码：9553

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20211210102844);WOS:【SCI-EXPANDED(收录号:WOS:000629659400001)】；

基金：This work was supported by NSFC/China (21788102, 21878087 and 21908060), Shanghai Municipal Science and Technology Major Project (Grant 2018SHZDZX03), the Innovation Program of Shanghai Municipal Education Commission, the Shuguang Program (18SG27), the China Postdoctoral Science Foundation (2019M651417).

语种：英文

外文关键词：cyanine; fluorescence imaging; hypoxia-dependent photolysis; near-infrared photocages; photoacoustic imaging

摘要：Photocaging holds promise for the precise manipulation of biological events in space and time. However, current near-infrared (NIR) photocages are oxygen-dependent for their photolysis and lack of timely feedback regulation, which has proven to be the major bottleneck for targeted therapy. Herein, we present a hypoxia-dependent photo-activation mechanism of dialkylamine-substituted cyanine (Cy-NH) accompanied by emissive fragments generation, which was validated with retrosynthesis and spectral analysis. For the first time, we have realized the orthogonal manipulation of this hypoxia-dependent photocaging and dual-modal optical signals in living cells and tumor-bearing mice, making a breakthrough in the direct spatiotemporal control and in vivo feedback regulation. This unique photoactivation mechanism overcomes the limitation of hypoxia, which allows site-specific remote control for targeted therapy, and expands the photo-trigger toolbox for on-demand drug release, especially in a physiological context with dual-mode optical imaging under hypoxia.