文献类型：期刊文献

英文题名：Why Is Tantalum Less Susceptible to Bacterial Infection?

作者：Chen, Xin[1,2];Bi, Yikang[3,4];Huang, Moran[5];Cao, Huiliang[6];Qin, Hui[1]

机构：[1]Shanghai Jiao Tong Univ Sch Med, Shanghai Peoples Hosp Affiliated 6, Dept Orthoped Surg, Shanghai 200233, Peoples R China;[2]Affiliated Hosp Xuzhou Med Univ, Dept Lab Med, Xuzhou 221002, Peoples R China;[3]Jiang Su Univ, Peoples Hosp 8, Dept Orthoped, Shanghai 200235, Peoples R China;[4]Shanghai Jiao Tong Univ Sch Med, Shanghai Peoples Hosp Affiliated 6, Dept Orthoped, Xuhui Branch, Shanghai 200235, Peoples R China;[5]Shanghai Jiao Tong Univ Sch Med, Shanghai Gen Hosp, Dept Orthoped Surg, Shanghai 201620, Peoples R China;[6]East China Univ Sci & Technol, Shanghai Engn Res Ctr Hierarch Nanomat, Sch Mat Sci & Engn, Key Lab Ultrafine Mat Minist Educ, Shanghai 200237, Peoples R China

年份：2022

卷号：13

期号：4

外文期刊名：JOURNAL OF FUNCTIONAL BIOMATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000900870400001)】；

基金：This work was jointly supported by grants from the National Natural Science Foundation of China (31771022, 32271399, and 31870945), and the Natural Science Foundation of Shanghai (21ZR1415700).

语种：英文

外文关键词：biomaterials; tantalum; race for the surface; implant-associated infection

摘要：Periprosthetic infection is one of the trickiest clinical problems, which often leads to disastrous consequences. The emergence of tantalum and its derivatives provides novel ideas and effective methods to solve this problem and has attracted great attention. However, tantalum was reported to have different anti-infective effects in vivo and in vitro, and the inherent antibacterial capability of tantalum is still controversial, which may restrict its development as an antibacterial material to some extent. In this study, the polished tantalum was selected as the experimental object, the implant-related tibia osteomyelitis model was first established to observe whether it has an anti-infective effect in vivo compared to titanium, and the early studies found that the tantalum had a lower infectious state in the implant-related tibia osteomyelitis model in vivo than titanium. However, further in vitro studies found that the polished tantalum was not superior to the titanium against bacterial adhesion and antibacterial efficacy. In addition, we focus on the state of interaction between cells, bacteria and materials to restore the internal environment as realistically as possible. We found that the adhesion of fibroblasts to tantalum was faster and better than that of titanium. Moreover, what is more, interesting is that, in the early period, bacteria were more likely to adhere to cells that had already attached to the surface of tantalum than to the bare surface of it, and over time, the cells eventually fell off the biomaterials and took away more bacteria in tantalum, making it possible for tantalum to reduce the probability of infection in the body through this mechanism. Moreover, these results also explained the phenomenon of the "race for the surface" from a completely different perspective. This study provides a new idea for further exploring the relationship between bacteria and host tissue cells on the implant surface and a meaningful clue for optimizing the preparation of antibacterial implants in the future.