文献类型：期刊文献

英文题名：Functional Poly(ε-caprolactone) Based Materials: Preparation, Self-Assembly and Application in Drug Delivery

作者：Xiao, Yan[1];Yuan, Ming[1];Zhang, Jun[1];Yan, Jinliang[1];Lang, Meidong[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat, Minist Educ,Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2014

卷号：14

期号：6

起止页码：781

外文期刊名：CURRENT TOPICS IN MEDICINAL CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000332777700009)】；

基金：Financial supports from the National Natural Science Foundation of China (51103041, 21274039), the Natural Science Foundation of Shanghai (11ZR1409200), the Scientific Research Foundation for the Returned Overseas Chinese Scholars State Education Ministry, Fundamental Research Funds for the Central Universities (WD0913008, WD1014017), Basic Research Key Program Project of Commission of Science and Technology of Shanghai (12JC1403000, 12JC1403100), and "Shu Guang" Project of Shanghai Municipal Education Commission were greatly acknowledged.

语种：英文

外文关键词：Functional poly-epsilon-caprolactone (PCL); modification; self-assembly; drug delivery

摘要：Recent advances in synthesis of functional poly-epsilon-caprolactone (PCL) and its self-assembly behavior, as well as application in drug delivery have been reviewed. Three strategies including end group functionalization, postpolymerization modification and new monomer preparation have been summarized to show possibilities for PCL derivatives. Complex architectures like cyclic and multi-arm PCL have been emphasized. Both chemical composition and topology have coordinately affected the property of PCL-based materials on the molecular level. A large variety of PCLs with sophisticated topology like block, graft, cyclic, and star have displayed versatile morphologies in solutions. These selfassembly aggregates have been applied as nano-scaled drug carries either to physically encapsulate or covalently conjugate drugs for controlled release. In particular, PCL with pendant groups has been extensively studied to illustrate the noncovalent interaction with drugs and the influence on the release profile. In general, functional PCL has shown great potential in construct of complicated supramolecular structures, and thus as ideal drug carriers for sustainable and targeted delivery.