文献类型：期刊文献

英文题名：Synthesis of the Scalarane Sesterterpenoid 16-deacetoxy-12-epi-scalarafuranacetate

作者：Chen, Xi-Bo[1];Yuan, Qian-Jia[1];Wang, Jing[1];Hua, Si-Kai[1];Ren, Jiangmeng[1];Zeng, Bu-Bing[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2011

卷号：76

期号：17

起止页码：7216

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000294242900027)，CCR-EXPANDED(收录号:WOS:000294242900027)】；

基金：This work was financially supported by the Shanghai Foundation of Science and Technology (09JC1404200), the National High Technology Research and Development Program of China (863 Program 2006AA09Z447, 2007AA02Z301 and 2011AA-10A207), and the China 111 Project (grant B07023).

语种：英文

摘要：The marine natural product 16-deacetoxy-12-epi-scalarafuranacetate, isolated from Spongua officinalis, was synthesized in 18 linear steps, starting from (-)-sclareol, with high stereoselectivity and an overall yield of 6.1%. The intermediate 16-deacetoxy-12-epi-scalarafuran could be easily transformed into a series of natural scalarane sesterterpenoids in a few steps.