文献类型：期刊文献

中文题名：复杂结构核-壳微颗粒的微流控制备方法

英文题名：Microfluidic Fabrication Method of Core-Shell Microparticles with Complex Structure

作者：邱阳[1];陈建琦[1];徐银香[1];王飞[1];汪华林[1]

机构：[1]华东理工大学国家环境保护化工过程环境风险评价与控制重点实验室,上海200237

年份：2015

卷号：41

期号：1

起止页码：103

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;Scopus;北大核心:【北大核心2014】；CSCD:【CSCD2015_2016】；

基金：国家杰出青年科学基金(51125032)

语种：中文

中文关键词：微流控;核-壳微颗粒;模块化组装;复杂微结构调控

外文关键词：microfluidic; core-shell microparticles; modular assembly; complex microstructure control

摘要：报道了一种基于微流控技术的复杂结构核-壳微颗粒的制备方法。对微流控装置进行模块化分析,组装了不同结构的微流控装置。装置具有成本低、易操作、扩展性强等优点。利用这些装置分别制备了包含不同尺寸或组分内液滴的W/O/W型复合乳液模板。之后结合紫外聚合反应,合成了包埋不同尺寸内核的核-壳微颗粒。此外,引入海藻酸水凝胶优化体系,解决了内核包埋物扩散问题,合成了包埋不同组分内核的核-壳微颗粒。对乳液模板及颗粒的形貌进行了表征,其具有单分散性高、结构均一性强的特点。此种复杂结构核-壳微颗粒在药物控释、微反应器、示踪颗粒等方面均有着极大的应用潜力。
A microfluidc fabrication method of core-shell microparticles with complex structure was reported.Microfluidic devices with different structures were assembled based on the modular analysis.The microfluidic device has advantages including low cost,easy operation and high scalability.Based on these devices,W/O/W multiple emulsion templates encapsulating inner droplets with different sizes or compositions were successfully generated.Then core-shell microparticles encapsulating cores with different sizes were fabricated via UV polymerization.Moreover,alginate hydrogel was introduced to restrain the embedding materials to diffuse from cores,and core-shell microparticles encapsulating cores with different compositions were also obtained.The morphology of emulsion templates and particles was observed by optical microscopy which showed narrow size distribution and uniform structure.These core-shell microparticles with complicated inner structure have promising applications in fields such as drug deliver and release,microreactor,and tracer particle.