文献类型：期刊文献

英文题名：Recent progress in the development of near-infrared fluorescent probes for bioimaging applications

作者：Guo, Zhiqian[1,2,3];Park, Sookil[4];Yoon, Juyoung[1];Shin, Injae[4]

机构：[1]Ewha Womans Univ, Dept Chem & Nano Sci, Global Top Res Program 5, Seoul 120750, South Korea;[2]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[4]Yonsei Univ, Dept Chem, Seoul 120749, South Korea

年份：2014

卷号：43

期号：1

起止页码：16

外文期刊名：CHEMICAL SOCIETY REVIEWS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000329070600003)】；

基金：This work was supported by the National Creative Research Initiative program (grant no. 2010-0018272 to I. S. and 2012R1A3A2048814 to J.Y.). Z. G. acknowledges NSFC/China (Grant 61177034) and the Shanghai Pujiang Program.

语种：英文

摘要：Near-infrared (NIR) fluorescent dyes have emerged as promising modalities for monitoring the levels of various biologically relevant species in cells and organisms. The use of NIR probes enables deep photon penetration in tissue, minimizes photo-damage to biological samples, and produces low background auto-fluorescence from biomolecules present in living systems. The number of new analyte-responsive NIR fluorescent probes has increased substantially in recent years as a consequence of intense research efforts. In this tutorial review, we highlight recent advances (2010-2013) made in the development and applications of NIR fluorescent probes. The review focuses on NIR fluorescent probes that have been devised to sense various biologically important species, including ROS/RNS, metal ions, anions, enzymes and other related species, as well as intracellular pH changes. The basic principles involved in the design of functional NIR fluorescent probes and suggestions about how to expand applications of NIR imaging agents are also described.