文献类型：期刊文献

英文题名：Phytic acid/magnesium ion complex coating on PEEK fiber woven fabric as an artificial ligament with anti-fibrogenesis and osteogenesis for ligament-bone healing

作者：Wang, Fan[1];Sun, Ping[2];Xie, En[1];Ji, Yinjun[3];Niu, Yunfei[3];Li, Fengqian[2];Wei, Jie[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Shanghai Eighth Peoples Hosp, Dept Orthopaed, Shanghai 200235, Peoples R China;[3]Second Mil Med Univ, Changhai Hosp, Dept Orthopaed, Shanghai 200433, Peoples R China

年份：2022

卷号：140

外文期刊名：BIOMATERIALS ADVANCES

收录：;EI(收录号：20223312584134);WOS:【SCI-EXPANDED(收录号:WOS:000861397600005)】；

基金：Acknowledgements The grants were from the National Natural Science Foundation of China (32171340, 81772343 and 81771990) and Key Medical Program of Science and Technology Development of Shanghai (20S31900400) and National Science Foundation of Shanghai (21ZR1447900) .

语种：英文

外文关键词：PEEK fibers; Phytic acid; Magnesium ions; Osteogenesis; Ligament -bone healing

摘要：Development of an artificial ligament possessing osteogenic activity to enhance ligament-bone healing for reconstruction of anterior cruciate ligament (ACL) is a great challenge. Herein, polyetheretherketone fibers (PKF) were coated with phytic acid (PA)/magnesium (Mg) ions complex (PKPM), which were woven into fabrics as an artificial ligament. The results demonstrated that PKPM with PA/Mg complex coating exhibited optimized surface properties with improved hydrophilicity and surface energy, and slow release of Mg ions. PKPM significantly enhanced responses of rat bone marrow stem cells in vitro. Moreover, PKPM remarkably promoted M2 macrophage polarization that upregulated production of anti-inflammatory cytokine while inhibited M1 macrophage polarization that downregulated production of pro-inflammatory cytokine in vitro. Further, PKPM inhibited fibrous encapsulation by preventing M1 macrophage polarization while promoted osteogenesis for ligament-bone healing by triggering M2 macrophage polarization in vivo. The results suggested that the down -regulation of M1 macrophage polarization for inhibiting fibrogenesis and upregulation of M2 macrophage po-larization for improving osteogenesis of PKPM were attributed to synergistic effects of PA and sustained release of Mg ions. In summary, PKPM with PA/Mg complex coating upregulated pro-osteogenic macrophage polari-zation that supplied a profitable anti-inflammatory environments for osteogenesis and ligament-bone healing, thereby possessing tremendous potential for reconstruction of ACL.